ReviewFrontiers in neuroscience2019
Origins of the Resting-State Functional MRI Signal: Potential Limitations of the "Neurocentric" Model.
Review in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Alcohol-induced changes in mesostriatal resting-state functional connectivity are linked to sensation seeking in young adults.Alcohol, clinical & experimental research · 2023Trial
- The Intrinsic Manifold of Spontaneous Activity Constrains Cortical Responses to Naturalistic Stimuli.bioRxiv : the preprint server for biology · 2026Article
- Assessing chance in neuro-vascular interactions.NeuroImage · 2026Article
- Dialogue mechanisms between astrocytic and neuronal networks: A whole-brain modelling approach.PLoS computational biology · 2025Article
- Differences in the amplitude of dynamic low-frequency fluctuations in primary angle-closure glaucoma are associated with gene-molecular multi-omics.Frontiers in medicine · 2025Article
- Association between neurovascular coupling and neural signals in the resting state as revealed by a combined fMRI and magnetoencephalography study in humans.Journal of neurophysiology · 2024Article
- Negative association between neurovascular coupling and cortical gray matter volume during the lifespan.Journal of neurophysiology · 2024Article
- Multimodal measures of spontaneous brain activity reveal both common and divergent patterns of cortical functional organization.Nature communications · 2024Article
- Increased Resting-State BOLD Turnover (TBOLD) is Associated With Decreased Cognitive Performance During Aging.Neuroscience insights · 2024Article
- Increased interhemispheric functional connectivity during non-dominant hand movement in right-handed subjects.iScience · 2023Article
- Multimodal measures of spontaneous brain activity reveal both common and divergent patterns of cortical functional organization.Research square · 2023Article
- Dissociation between phase and power correlation networks in the human brain is driven by co-occurrent bursts.Communications biology · 2023Article
- Reproducibility of regional structural and functional MRI networks in cerebral small vessel disease compared to age matched and stroke-free controls.Cerebral circulation - cognition and behavior · 2023Article
- Heritability of brain neurovascular coupling.Journal of neurophysiology · 2022Article
- Normal aging in mice is associated with a global reduction in cortical spectral power and network-specific declines in functional connectivity.NeuroImage · 2022Article
- Computing hemodynamic response functions from concurrent spectral fiber-photometry and fMRI data.Neurophotonics · 2022Article
- Toward an integrative neurovascular framework for studying brain networks.Neurophotonics · 2022Article
- Personalized brain models identify neurotransmitter receptor changes in Alzheimer's disease.Brain : a journal of neurology · 2022Article
- Tau deposition patterns are associated with functional connectivity in primary tauopathies.Nature communications · 2022Article
- The Pathobiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Case for Neuroglial Failure.Frontiers in cellular neuroscience · 2022Article
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Resting-state functional connectivity (rsFC) is emerging as a research tool for systems and clinical neuroscience. The mechanism underlying resting-state functional MRI (rsfMRI) signal, however, remains incompletely understood. A widely held assumption is that the spontaneous fluctuations in blood oxygenation level-dependent (BOLD) signal reflect ongoing neuronal processes (herein called "neurocentric" model). In support of this model, evidence from human and animal studies collectively reveals that the spatial synchrony of spontaneously occurring electrophysiological signal recapitulates BOLD rsFC networks. Two recent experiments from independent labs designed to specifically examine neuronal origins of rsFC, however, suggest that spontaneously occurring neuronal events, as assessed by multiunit activity or local field potential (LFP), although statistically significant, explain only a small portion (∼10%) of variance in resting-state BOLD fluctuations. These two studies, although each with its own limitations, suggest that the spontaneous fluctuations in rsfMRI, may have complex cellular origins, and the "neurocentric" model may not apply to all brain regions.
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