ArticleFrontiers in neuroscience2019
Functional MRI Readouts From BOLD and Diffusion Measurements Differentially Respond to Optogenetic Activation and Tissue Heating.
Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Optogenetic fMRI for Brain-Wide Circuit Analysis of Sensory Processing.International journal of molecular sciences · 2022Pooled it
- Distinct neurochemical influences on fMRI response polarity in the striatum.Nature communications · 2024Article
- Optogenetic stimulation of anterior insular cortex neurons in male rats reveals causal mechanisms underlying suppression of the default mode network by the salience network.Nature communications · 2023Article
- Detection of laser-associated heating in the brain during simultaneous fMRI and optogenetic stimulation.Magnetic resonance in medicine · 2023Article
- The impact of vasomotion on analysis of rodent fMRI data.Frontiers in neuroscience · 2023Article
- Hybrid fiber optic-fMRI for multimodal cell-specific recording and manipulation of neural activity in rodents.Neurophotonics · 2022Review
- Optogenetics for light control of biological systems.Nature reviews. Methods primers · 2022Article
- Cerebro-cerebellar interactions in nonhuman primates examined by optogenetic functional magnetic resonance imaging.Cerebral cortex communications · 2022Article
- High-sensitivity detection of optogenetically-induced neural activity with functional ultrasound imaging.NeuroImage · 2021Article
- Combining brain perturbation and neuroimaging in non-human primates.NeuroImage · 2021Review
- Central amygdala circuitry modulates nociceptive processing through differential hierarchical interaction with affective network dynamics.Communications biology · 2021Article
- Differential effects of aquaporin-4 channel inhibition on BOLD fMRI and diffusion fMRI responses in mouse visual cortex.PloS one · 2020Article
- Optogenetic fMRI reveals therapeutic circuits of subthalamic nucleus deep brain stimulation.Brain stimulationArticle
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Functional blood-oxygenation-level-dependent (BOLD) MRI provides a brain-wide readout that depends on the hemodynamic response to neuronal activity. Diffusion fMRI has been proposed as an alternative to BOLD fMRI and has been postulated to directly rely on neuronal activity. These complementary functional readouts are versatile tools to be combined with optogenetic stimulation to investigate networks of the brain. The cell-specificity and temporal precision of optogenetic manipulations promise to enable further investigation of the origin of fMRI signals. The signal characteristics of the diffusion fMRI readout vice versa may better resolve network effects of optogenetic stimulation. However, the light application needed for optogenetic stimulation is accompanied by heat deposition within the tissue. As both diffusion and BOLD are sensitive to temperature changes, light application can lead to apparent activations confounding the interpretation of fMRI data. The degree of tissue heating, the appearance of apparent activation in different fMRI sequences and the origin of these phenomena are not well understood. Here, we disentangled apparent activations in BOLD and diffusion measurements in rats from physiological activation upon sensory or optogenetic stimulation. Both, BOLD and diffusion fMRI revealed similar signal shapes upon sensory stimulation that differed clearly from those upon heating. Apparent activations induced by high-intensity light application were dominated by T
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