ArticleCurrent biology : CB2019
Dynamic Regulation of Adult-Specific Functions of the Nervous System by Signaling from the Reproductive System.
Article in Current biology : CB, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Accelerated hermaphrodite maturation on male pheromones suggests a general principle of coordination between larval behavior and development.Development (Cambridge, England) · 2024Article
- The roles of TGFβ and serotonin signaling in regulating proliferation of oocyte precursors and germline aging.bioRxiv : the preprint server for biology · 2024Article
- A single neuron in C. elegans orchestrates multiple motor outputs through parallel modes of transmission.Current biology : CB · 2023Article
- Serotonergic signaling plays a deeply conserved role in improving oocyte quality.Developmental biology · 2023Article
- A single neuron inbioRxiv : the preprint server for biology · 2023Article
- Sex-specificity of the C. elegans metabolome.Nature communications · 2023Article
- The serotonin circuit that coordinates germline proliferation and egg laying with other reproductive functions inProceedings. Biological sciences · 2022Article
- A male pheromone that improves the quality of the oogenic germline.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Dynamic functional connectivity in the static connectome of Caenorhabditis elegans.Current opinion in neurobiology · 2022Review
- The roles of several sensory neurons and the feedback from egg laying in regulating the germline response to a sex pheromone inmicroPublication biology · 2022Article
- ODR-1 acts in AWB neurons to determine the sexual identity ofmicroPublication biology · 2022Article
- Article
- Chemosensory signal transduction in Caenorhabditis elegans.Genetics · 2021Review
- Article
- Recent Advances in the Genetic, Anatomical, and Environmental Regulation of theJournal of developmental biology · 2020Review
- Chemical Communication: Linking Behavior and Physiology.Current biology : CB · 2019Article
- Neuromodulators: an essential part of survival.Journal of neurogeneticsReview
- Small molecule signals mediate social behaviors inJournal of neurogeneticsReview
Corrections and comments
- Commented on by
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Unlike juveniles, adult animals engage in suites of behaviors related to the search for and selection of potential mates and mating, including appropriate responses to sex pheromones. As in other species [1], male sex pheromones modulate several behaviors and physiological processes in C. elegans hermaphrodites [2-5]. In particular, one of these small-molecule signals, an ascaroside ascr#10, causes reduced exploration, more avid mating, and improved reproductive performance (see the accompanying paper by Aprison and Ruvinsky in this issue of Current Biology) [6]. Here, we investigated the mechanism that restricts pheromone response to adult hermaphrodites. Unexpectedly, we found that attainment of developmental adulthood was not alone sufficient for the behavioral response to the pheromone. To modify exploratory behavior in response to male pheromone, adult hermaphrodites also require functional germline and egg-laying apparatus. We show that this dependence of behavior on the reproductive system is due to feedback from the vulva muscles that reports ongoing reproduction to the nervous system. Our results reveal an activity-dependent conduit by which the reproductive system continuously licenses adult behaviors, including appropriate responses to the pheromones of the opposite sex. More broadly, our results suggest that signals from peripheral organs may serve as an important component of assuring age-appropriate functions of the nervous system.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.