ArticleCurrent biology : CB2019
Coordinated Behavioral and Physiological Responses to a Social Signal Are Regulated by a Shared Neuronal Circuit.
Article in Current biology : CB, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed.
- Sex Alters Hypoxic Responses inmicroPublication biology · 2026Article
- Comprehensive analysis of the C. elegans connectome reveals novel circuits and functions of previously unstudied neurons.PLoS biology · 2024Article
- The roles of TGFβ and serotonin signaling in regulating proliferation of oocyte precursors and germline aging.bioRxiv : the preprint server for biology · 2024Article
- FUNCTIONS OFbioRxiv : the preprint server for biology · 2024Article
- Serotonin neurons in mating female mice are activated by male ejaculation.Current biology : CB · 2023Article
- The synaptic basis for sexual dimorphism in the invertebrate nervous system.Current opinion in neurobiology · 2023Review
- Serotonergic signaling plays a deeply conserved role in improving oocyte quality.Developmental biology · 2023Article
- Sex-specificity of the C. elegans metabolome.Nature communications · 2023Article
- The serotonin circuit that coordinates germline proliferation and egg laying with other reproductive functions inProceedings. Biological sciences · 2022Article
- A male pheromone that improves the quality of the oogenic germline.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Dynamic functional connectivity in the static connectome of Caenorhabditis elegans.Current opinion in neurobiology · 2022Review
- The roles of several sensory neurons and the feedback from egg laying in regulating the germline response to a sex pheromone inmicroPublication biology · 2022Article
- ODR-1 acts in AWB neurons to determine the sexual identity ofmicroPublication biology · 2022Article
- Article
- Chemosensory signal transduction in Caenorhabditis elegans.Genetics · 2021Review
- Article
- Recent Advances in the Genetic, Anatomical, and Environmental Regulation of theJournal of developmental biology · 2020Review
- Chemical Communication: Linking Behavior and Physiology.Current biology : CB · 2019Article
- Social and sexual behaviors inJournal of neurogeneticsArticle
- What can a worm learn in a bacteria-rich habitat?Journal of neurogeneticsReview
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Successful reproduction in animals requires orchestration of behavior and physiological processes. Pheromones can induce both "releaser" (behavioral) and "priming" (physiological) effects [1] in vertebrates [2, 3] and invertebrates [4, 5]. Therefore, understanding the mechanisms underlying pheromone responses could reveal how reproduction-related behaviors and physiology are coordinated. Here, we describe a neuronal circuit that couples the reproductive system and behavior in adult Caenorhabditis elegans hermaphrodites. We found that the response of the oogenic germline to the male pheromone requires serotonin signal from NSM and HSN neurons that acts via the mod-1 receptor in AIY and RIF interneurons and is antagonized by pigment-dispersing factor (PDF). Surprisingly, the same neurons and pathways have been previously implicated in regulation of exploratory behavior in the absence of male-produced signals [6]. We demonstrate that male pheromone acts via this circuit in hermaphrodites to reduce exploration and decrease mating latency, thereby tuning multiple fitness-proximal processes. Our results demonstrate how a single circuit could coordinate behavioral and physiological responses to the environment, even those that unfold on different timescales. Our findings suggest the existence of a centralized regulatory mechanism that balances organismal resources between reproductive investment and somatic maintenance.
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Registered trials
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