ArticleCurrent biology : CB2019
Target-wide Induction and Synapse Type-Specific Robustness of Presynaptic Homeostasis.
Article in Current biology : CB, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 52 citations in OpenAlex.
- Complete muscle denervation triggers compensatory sprouting of a bystander tonic motor neuron iniScience · 2026Article
- Motor neurons integrate cholinergic inputs through spatial organization of diverse nicotinic receptors.PNAS nexus · 2026Article
- Article
- Activity-Dependent Increases in Quantal Size at theJournal of developmental biology · 2025Article
- Deficiency in transmitter release triggers homeostatic transcriptional changes that increase presynaptic excitability.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Balanced synapse-to-synapse short-term plasticity ensures constant transmitter release.Current biology : CB · 2025Article
- Building and modifying diverse synaptic properties: Insights from Drosophila.Current opinion in neurobiology · 2025Review
- Behavioral resilience via dynamic circuit firing homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Distinct input-specific mechanisms enable presynaptic homeostatic plasticity.Science advances · 2025Article
- CaeLife · 2024Article
- Distinct input-specific mechanisms enable presynaptic homeostatic plasticity.bioRxiv : the preprint server for biology · 2024Article
- CabioRxiv : the preprint server for biology · 2024Article
- Physiologic and Nanoscale Distinctions Define Glutamatergic Synapses in Tonic vs Phasic Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Molecular Logic of Synaptic Diversity BetweenbioRxiv : the preprint server for biology · 2023Article
- Unraveling the mysteries of dendritic spine dynamics: Five key principles shaping memory and cognition.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2023Article
- Activation and expansion of presynaptic signaling foci drives presynaptic homeostatic plasticity.Neuron · 2022Article
- Article
- Homeostatic Regulation of Motoneuron Properties in Development.Advances in neurobiology · 2022Review
- The calcineurin regulator Sarah enables distinct forms of homeostatic plasticity at theFrontiers in synaptic neuroscience · 2022Article
- Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
Presynaptic homeostatic plasticity (PHP) is an evolutionarily conserved form of adaptive neuromodulation and is observed at both central and peripheral synapses. In this work, we make several fundamental advances by interrogating the synapse specificity of PHP. We define how PHP remains robust to acute versus long-term neurotransmitter receptor perturbation. We describe a general PHP property that includes global induction and synapse-specific expression mechanisms. Finally, we detail a novel synapse-specific PHP expression mechanism that enables the conversion from short- to long-term PHP expression. If our data can be extended to other systems, including the mammalian central nervous system, they suggest that PHP can be broadly induced and expressed to sustain the function of complex neural circuitry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.