Evidence map›Paper›PMID 31708243›Full record

ArticleJournal of biomechanics2020

An ex vivo technique for quantifying mouse lung injury using ultrasound surface wave elastography.

Boran Zhou, Kyle J Schaefbauer, Ashley M Egan, Eva M Carmona Porquera, Andrew H Limper, Xiaoming Zhang

Open access · greenAbstract read
In one paragraph

Article in Journal of biomechanics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Grading Bleomycin-Induced Pulmonary Fibrosis in ex vivo Mouse Lungs Using Ultrasound Image Analysis.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2021
    Article
  4. Article
  5. Ultrasound Elastography for Lung Disease Assessment.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Boran ZhouDepartment of Radiology, Mayo Clinic, United States.
Kyle J SchaefbauerThoracic Disease Research Unit, Mayo Clinic, United States.
Ashley M EganDepartment of Pulmonary and Critical Care Medicine, Mayo Clinic, United States.
Eva M Carmona PorqueraThoracic Disease Research Unit, Mayo Clinic, United States; Department of Pulmonary and Critical Care Medicine, Mayo Clinic, United States.
Andrew H LimperThoracic Disease Research Unit, Mayo Clinic, United States; Department of Pulmonary and Critical Care Medicine, Mayo Clinic, United States.
Xiaoming ZhangDepartment of Radiology, Mayo Clinic, United States. Electronic address: zhang.xiaoming@mayo.edu.
Mayo Clinic in Arizona · USMayo Clinic in Florida · USWinnMed · US

Funding

Measurement of surface lung tissue using ultrasoundR01HL125234 · NHLBI · MAYO CLINIC ROCHESTER · PI ZHANG, XIAOMING · 2015 to 2018
$1.5M
NHLBI NIH HHS R01 HL125234
6 · The paper itself

Abstract

Idiopathic pulmonary fibrosis is a progressively fatal disease with limited treatments. The bleomycin mouse model is often used to simulate the disease process in laboratory studies. The aim of this study was to develop an ex vivo technique for assessing mice lung injury using lung ultrasound surface wave elastography (LUSWE) in the bleomycin mouse model. The surface wave speeds were measured at three frequencies of 100, 200, and 300 Hz for mice lungs from control, mild, and severe groups. The results showed significant differences in the lung surface wave speeds, pulse oximetry, and compliance between control mice and mice with severe pulmonary fibrosis. LUSWE is an evolving technique for evaluating lung stiffness and may be useful for assessing pulmonary fibrosis in the bleomycin mouse model.

Indexed as

Elasticity Imaging TechniquesAnimalsBiomechanical PhenomenaDisease Models, AnimalLungLung InjuryMiceMice, Inbred C57BLBleomycin (BLM)Idiopathic pulmonary fibrosis (IPF)Lung ultrasound surface wave elastography (LUSWE)MiceSurface wave speed

Identifiers

PMID31708243
PMCPMC6930343
OpenAlexW2987787071

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.