Evidence map›Paper›PMID 31708169›Full record

ArticleEnvironmental research2019

Cancer risk from air toxics in relation to neighborhood isolation and sociodemographic characteristics: A spatial analysis of the St. Louis metropolitan area, USA.

Christine C Ekenga, Cheuk Yui Yeung, Masayoshi Oka

Abstract read
In one paragraph

Article in Environmental research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Impact of Pollution on Cancer: A Systematic Review and Meta-Analysis with Focus on Air Pollution.International journal of environmental research and public health · 2026
    Pooled it
  2. Pooled it
  3. Article
  4. Identifying differences in U.S. exposure to ubiquitous carcinogens.International journal of hygiene and environmental health · 2025
    Article
  5. Article
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  10. Inequalities in Environmental Cancer Risk and Carcinogen Exposures: A Scoping Review.International journal of environmental research and public health · 2023
    Article
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  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Christine C EkengaBrown School, Washington University in St. Louis, St. Louis, MO, USA. Electronic address: ekengac@wustl.edu.
Cheuk Yui YeungDivision of Occupational and Environmental Medicine, University of California, Irvine School of Medicine, Irvine, CA, USA. Electronic address: c.yeung@wustl.edu.
Masayoshi OkaFaculty of Management, Josai University, Sakado, Saitama, Japan. Electronic address: moka@alumni.harvard.edu.

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
Healthier Workforce Center of the MidwestU19OH008868 · OH · UNIVERSITY OF IOWA · PI ROHLMAN, DIANE S · 2006 to 2025
$19.8M
NCI NIH HHS P30 CA091842NIOSH CDC HHS U19 OH008868
6 · The paper itself

Abstract

backgroundA growing body of research has examined relationships between neighborhood characteristics and exposure to air toxics in the United States. However, a limited number of studies have addressed neighborhood isolation, a measure of spatial segregation. We investigated the spatial distribution of carcinogenic air toxics in the St. Louis metropolitan area and tested the hypothesis that neighborhood isolation and sociodemographic characteristics are associated with exposure to carcinogenic air toxics.

methodsWe obtained lifetime air toxics cancer risk data from the United States Environmental Protection Agency's National Air Toxic Assessment and sociodemographic data from the American Community Survey. We used geographic information systems to identify statistically significant clusters of census tracts with elevated all-site cancer risk due to air toxics in the St. Louis metropolitan area. Relative Risks (RR) were estimated for the association between neighborhood characteristics and air toxic hot spots. Using a local spatial isolation index to evaluate residential segregation, we also evaluated the association between neighborhood racial and economic isolation and air toxic hot spots.

resultsApproximately 14% (85 of the 615) of census tracts had elevated cancer risk due to air toxics (p < 0.01). These air toxic hot spots were independently associated with neighborhoods with high levels of poverty and unemployment and low levels of education. Census tracts with the highest levels of both racial isolation of Blacks and economic isolation of poverty were more likely to be located in air toxic hotspots than those with low combined racial and economic isolation (RR = 5.34; 95% CI = 3.10-9.22).

conclusionsThese findings provide strong evidence of unequal distribution of carcinogenic air toxics in the St. Louis metropolitan area. Study results may be used to inform public health efforts to eliminate sociodemographic inequalities in exposure to air pollutants.

Indexed as

Air PollutantsAir PollutionCitiesDemographyEnvironmental ExposureHumansMissouriNeoplasmsResidence CharacteristicsRisk AssessmentSocioeconomic FactorsSpatial AnalysisUnited StatesAir PollutantsAir pollutionCancerDisparityGeographic information systemSociodemographic

Identifiers

PMID31708169
PMCPMC6901107

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.