ArticleCell2019
Long-Term Culture Captures Injury-Repair Cycles of Colonic Stem Cells.
Open access · hybridAbstract read
In one paragraph
Article in Cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 134 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
134citing papers in PubMed, 2 pooled it
10.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
134 citing papers in PubMed, 2 syntheses or guidelines pooled it, 201 citations in OpenAlex.
- Guiding Principles: Reporting Elements for Gastrointestinal Organoid Research.Cellular and molecular gastroenterology and hepatology · 2026Guideline
- Organoid Models of Colorectal Pathology: Do They Hold the Key to Personalized Medicine? A Systematic Review.Diseases of the colon and rectum · 2020Pooled it
- Updated Protocols for 3D and 2D Culture and Histological Analysis of Intestinal Organoids.Methods in molecular biology (Clifton, N.J.) · 2027Article
- Multimodal learning enables chat-based exploration of single-cell data.Nature biotechnology · 2026Article
- A spatial and temporal transcriptomic atlas of mouse intestinal regeneration in the jejunum.Nature communications · 2026Article
- Chrono-atlas of cell-type specific daily gene expression rhythms in the regenerating colon.Nature communications · 2026Article
- Article
- Paracrine iron activates HopxJournal of advanced research · 2026Article
- An inflammasome-driven differentiation program in intestinal stem cells protects against Salmonella infection.Nature immunology · 2026Article
- Colonic epithelial regeneration shapes susceptibility tobioRxiv : the preprint server for biology · 2026Article
- Quantifying the fidelity of in vitro human cell culture systems using a biomedical foundation model.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A microbiota-IPA axis facilitates intestinal stem cell-mediated regeneration in colitis through a Hopx-associated program.Nature communications · 2026Article
- Development and characterization of immortalized mouse intestinal epithelial cell lines.Scientific reports · 2026Article
- Microbiota-derived IPA protects against colitis by regulating intestinal HMGCS2-mediated ketogenesis to facilitate mucosal healing.Nature communications · 2026Article
- Spatial immune niche remodeling of the neutrophil-macrophage axis inchronic liver disease.Frontiers in cell and developmental biology · 2026Review
- HOPX is required for the generation of umbilical cord blood-derived memory-like NK cells induced by three cytokines.Frontiers in immunology · 2026Article
- Competitive Binding of UBA52 and HOPX Modulates β-catenin Stability in Colorectal Cancer in the Context of High-Iron Intake.International journal of biological sciences · 2026Article
- Obesity impairs gut repair via AFABP-mediated iron overload in intestinal stem cells.Nature metabolism · 2026Article
- Comprehensive Colorectal Cancer Stem Cell Transcriptomic Signatures That Can Predict Patient Prognostic Outcomes.Cancer science · 2026Article
- Biomechanical Phenotyping Reveals Unique Mechanobiological Signatures of Early-Onset Colorectal Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
74 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
20 authors at 2 institutions in 1 country.
Yi WangDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
I-Ling ChiangDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Takahiro E OharaDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Satoru FujiiDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Jiye ChengDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Brian D MueggeDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Aaron Ver HeulDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Nathan D HanDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Qiuhe LuDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Shanshan XiongDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Feidi ChenDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Chin-Wen LaiDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Hana JanovaDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Renee WuDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Charles E WhitehurstBoehringer Ingelheim Pharmaceuticals, Immunology and Respiratory Disease Research, Ridgefield, CT 06877, USA.
Kelli L VanDussenDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Ta-Chiang LiuDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Jeffrey I GordonDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA; The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
L David SibleyDepartment of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Thaddeus S StappenbeckDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA. Electronic address: stappenb@wustl.edu.
Washington University in St. Louis · USBoehringer Ingelheim (United States) · US
Funding
Washington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Nicholas O. Davidson · 2000 to 2026
$30.8MREGULATION OF GENE EXPRESSION - SMALL INTESTINER01DK030292 · NIDDK · WASHINGTON UNIVERSITY · PI JEFFREY I GORDON, ANDREI L OSTERMAN · 1986 to 2026
$6.5MPediatric Gastroenterology Research Training ProgramT32DK077653 · NIDDK · WASHINGTON UNIVERSITY · PI PHILLIP I TARR · 2007 to 2026
$5.8MREGULATION OF GENE EXPRESSION IN THE SMALL INTESTINER37DK030292 · NIDDK · WASHINGTON UNIVERSITY · PI GORDON, JEFFREY I · 1993 to 2015
$4.0MEffect of Microbial Metabolites on Growth of CryptosporidiumR01AI145496 · NIAID · WASHINGTON UNIVERSITY · PI SIBLEY, L. DAVID · 2020 to 2023
$2.7MDEFINING THE BASIS OF EPITHELIAL DEFECTS IN CROHN'S DISEASE PATIENTSK01DK109081 · NIDDK · WASHINGTON UNIVERSITY · PI VANDUSSEN, KELLI LYNN · 2016 to 2020
$737kEnteroendocrine cell plasticity during intestinal injuryK08DK122101 · NIDDK · WASHINGTON UNIVERSITY · PI MUEGGE, BRIAN DAVID · 2019 to 2019
$122kNIAID NIH HHS R01 AI145496NIDDK NIH HHS K01 DK109081NIDDK NIH HHS K08 DK122101NIDDK NIH HHS P30 DK052574NIDDK NIH HHS R01 DK030292NIDDK NIH HHS R37 DK030292NIDDK NIH HHS T32 DK077653
Abstract
The colonic epithelium can undergo multiple rounds of damage and repair, often in response to excessive inflammation. The responsive stem cell that mediates this process is unclear, in part because of a lack of in vitro models that recapitulate key epithelial changes that occur in vivo during damage and repair. Here, we identify a Hopx
Indexed as
3T3 CellsAnimalsCell Culture TechniquesColitisColonEpithelial CellsHomeodomain ProteinsMiceModels, BiologicalOxygenRegenerationStem CellsStress, PhysiologicalHod protein, mouseHomeodomain ProteinsOxygenair-liquid interfacecolitiscolonHopXhypoxiaintestineLgr5stem cellTranswellunfolded protein response
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.