Evidence map›Paper›PMID 31708045›Full record

ReviewChild and adolescent psychiatric clinics of North America2020

Genetics of Childhood-onset Schizophrenia 2019 Update.

Jennifer K Forsyth, Robert F Asarnow

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Child and adolescent psychiatric clinics of North America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Childhood-Onset Psychosis: A large UK case series.European child & adolescent psychiatry · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. International journal of molecular sciences · 2022
    Article
  10. Article
  11. Article
  12. Review
  13. Reframing Psychiatry for Precision Medicine.Journal of personalized medicine · 2020
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jennifer K ForsythDepartment of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90095, USA. Electronic address: jforsyth@mednet.ucla.edu.
Robert F AsarnowDepartment of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, 760 Westwood Plaza, Los Angeles, CA 90095, USA; Department of Psychology, University of California, Los Angeles, 502 Portola Plaza Los Angeles, CA 90095, USA; Brain Research Institute, University of California, Los Angeles, 695 Charles E Young Dr S, Los Angeles, CA 90095, USA. Electronic address: rasarnow@mednet.ucla.edu.
University of California, Los Angeles · US

Funding

Cortical-Striatal Dysfunction and Vulnerability to SchizophreniaR24MH072697 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ASARNOW, ROBERT F · 2005 to 2007
$1.0M
From Genotypes to Phenotypes in Schizophrenia: A Developmental Functional Genomics ApproachK08MH118577 · NIMH · UNIVERSITY OF WASHINGTON · PI FORSYTH, JENNIFER KATHERINE · 2018 to 2022
$734k
NIMH NIH HHS K08 MH118577NIMH NIH HHS R24 MH072697
6 · The paper itself

Abstract

The genetic architecture of schizophrenia is complex and highly polygenic. This article discusses key findings from genetic studies of childhood-onset schizophrenia (COS) and the more common adult-onset schizophrenia (AOS), including studies of familial aggregation and common, rare, and copy number variants. Extant literature suggests that COS is a rare variant of AOS involving greater familial aggregation of schizophrenia spectrum disorders and a potentially higher occurrence of pathogenic copy number variants. The direct utility of genetics to clinical practice for COS is currently limited; however, identifying common pathways through which risk genes affect brain function offers promise for novel interventions.

Indexed as

Genome-Wide Association StudyAge of OnsetChildHumansNeurodevelopmental DisordersSchizophreniaAutism spectrum disorderChildhood-onset schizophreniaCommon variantsCopy number variantsDe novo mutationsGeneticsGWASRare variants

Identifiers

PMID31708045
PMCPMC6954004
OpenAlexW2981149635

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.