Observational studyJournal of cardiovascular pharmacology and therapeutics2020
Multicenter Analysis of Dosing Protocols for Sotalol Initiation.
Observational study in Journal of cardiovascular pharmacology and therapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- Impact of an Alert-Based Inpatient Clinical Decision Support Tool to Prevent Drug-Induced Long QT Syndrome: Large-Scale, System-Wide Observational Study.Journal of medical Internet research · 2025Observational
- Safety of outpatient commencement of sotalol.Heart rhythm O2 · 2024Article
- Is the reliability of wastewater-based epidemiology affected by season? Comparative analysis with pharmaceuticals prescriptions.Environmental science and pollution research international · 2024Article
- Class III Antiarrhythmics and Periprocedural Torsades de Pointes.JACC. Case reports · 2023Article
- Economics and outcomes of sotalol in-patient dosing approaches in patients with atrial fibrillation.Journal of cardiovascular electrophysiology · 2022Article
- Outpatient Initiation of Sotalol in Patients with Atrial Fibrillation: Utility of Cardiac Implantable Electronic Devices for Therapy Monitoring.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2021Article
- Management of tachyarrhythmias in pregnancy - A review.Obstetric medicine · 2020Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
Sotalol, a Vaughan-Williams Class III antiarrhythmic medication, is used to manage atrial arrhythmias. Due to its QT-prolonging effect and subsequent increased risk of torsade de pointes, many centers admit patients during the initial dosing period. Despite its widespread use, little information is available regarding dosing protocols during this period. In this multicenter investigation, dosing protocols in patients initiating sotalol therapy were examined to identify predictors of successful sotalol initiation. Over a 4-year period, patients admitted to 5 hospitals in the United States for inpatient telemetry monitoring during initiation for nonresearch purposes were enrolled. A 3-day course of 5 of 6 doses of sotalol was considered successful completion of the loading protocol. Of the 213 enrolled patients, over 90% were successfully discharged on sotalol. Significant bradycardia, ineffectiveness, and excessive QT prolongation were reasons for failed completion. Absence of a dose adjustment was a strong predictor of successful initiation (odds ratio: 6.6, 95% confidence interval: 1.3-32.7,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.