Trial reportCirculation2020
HIV Infection Is Associated With Variability in Ventricular Repolarization: The Multicenter AIDS Cohort Study (MACS).
Trial report in Circulation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Arrhythmogenic effects of acute electronic cigarette compared to tobacco cigarette smoking in people living with HIV.Physiological reports · 2024Trial
- Association of human immunodeficiency virus with acute myocardial infarction and presumed sudden cardiac death.Resuscitation plus · 2025Article
- Reduced heart rate variability is associated with altered clinical laboratory profile in people living with HIV.Brain, behavior, & immunity - health · 2024Article
- Cardiac and Renal Comorbidities in Aging People Living With HIV.Circulation research · 2024Review
- Classification of Free-Living Body Posture with ECG Patch Accelerometers: Application to the Multicenter AIDS Cohort Study.Statistics in biosciences · 2024Article
- Elevated Interleukin-6 Levels Are Associated With an Increased Risk of QTc Interval Prolongation in a Large Cohort of US Veterans.Journal of the American Heart Association · 2024Observational
- Article
- Association Between Left Ventricular Scar and Ventricular Ectopy in People Living With and Without HIV.JACC. Advances · 2023Article
- Fir(e)ing the Rhythm: Inflammatory Cytokines and Cardiac Arrhythmias.JACC. Basic to translational science · 2023Review
- Social Disparities among Sudden Death victims with HIV.AIDS and behavior · 2022Article
- Patterns of objectively measured physical activity differ between men living with and without HIV.AIDS (London, England) · 2022Article
- Prevention of heart failure, tachyarrhythmias and sudden cardiac death in HIV.Current opinion in HIV and AIDS · 2022Review
- CARDIOVASCULAR DISEASE IN HIV.Transactions of the American Clinical and Climatological Association · 2022Article
- Suspected bradycardia due to interactions between HIV protease inhibitors and lidocaine: a case report.Journal of dental anesthesia and pain medicine · 2021Article
- Association between exposure to Efavirenz and substrates of dysrhythmia in HIV-infected young adults.Clinical cardiology · 2021Article
- Methadone Destabilizes Cardiac Repolarization During Sleep.Clinical pharmacology and therapeutics · 2021Article
- Characteristics of the MACS/WIHS Combined Cohort Study: Opportunities for Research on Aging With HIV in the Longest US Observational Study of HIV.American journal of epidemiology · 2021Observational
- Sudden cardiac death in HIV-infected patients: A contemporary review.Clinical cardiology · 2021Review
- Heart Rate Influence on the QT Variability Risk Factors.Diagnostics (Basel, Switzerland) · 2020Article
- Sympathetic function and markers of inflammation in well-controlled HIV.Brain, behavior, & immunity - health · 2020Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundPeople living with human immunodeficiency virus (HIV+) have greater risk for sudden arrhythmic death than HIV-uninfected (HIV-) individuals. HIV-associated abnormal cardiac repolarization may contribute to this risk. We investigated whether HIV serostatus is associated with ventricular repolarization lability by using the QT variability index (QTVI), defined as a log measure of QT-interval variance indexed to heart rate variance.
methodsWe studied 1123 men (589 HIV+ and 534 HIV-) from MACS (Multicenter AIDS Cohort Study), using the ZioXT ambulatory electrocardiography patch. Beat-to-beat analysis of up to 4 full days of electrocardiographic data per participant was performed using an automated algorithm (median analyzed duration [quartile 1-quartile 3]: 78.3 [66.3-83.0] hours/person). QTVI was modeled using linear mixed-effects models adjusted for demographics, cardiac risk factors, and HIV-related and inflammatory biomarkers.
resultsMean (SD) age was 60.1 (11.9) years among HIV- and 54.2 (11.2) years among HIV+ participants (
conclusionsHIV+ men have greater beat-to-beat variability in QT interval (QTVI) than HIV- men, especially in the setting of HIV viremia and heightened inflammation. Among HIV+ men, higher QTVI suggests ventricular repolarization lability, which can increase susceptibility to arrhythmias, whereas lower heart rate variability signals a component of autonomic dysfunction.
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