Evidence map›Paper›PMID 31707632›Full record

ArticleMolecular neurobiology2020

The N-Terminal Polybasic Region of Prion Protein Is Crucial in Prion Pathogenesis Independently of the Octapeptide Repeat Region.

Nandita Rani Das, Hironori Miyata, Hideyuki Hara, Junji Chida, Keiji Uchiyama, Kentaro Masujin, Hitomi Watanabe, Gen Kondoh, Suehiro Sakaguchi

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. N-Terminal Regions of Prion Protein: Functions and Roles in Prion Diseases.International journal of molecular sciences · 2020
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Nandita Rani DasDivision of Molecular Neurobiology, The Institute for Enzyme Research (KOSOKEN), Tokushima University, 3-18-15 Kuramoto, Tokushima, 770-8503, Japan.
Hironori MiyataAnimal Research Center, School of Medicine, University of Occupational and Environmental Health, 1-1 Yahatanishi-Iseigaoka, Kitakyushu, 807-8555, Japan.
Hideyuki HaraDivision of Molecular Neurobiology, The Institute for Enzyme Research (KOSOKEN), Tokushima University, 3-18-15 Kuramoto, Tokushima, 770-8503, Japan.
Junji ChidaDivision of Molecular Neurobiology, The Institute for Enzyme Research (KOSOKEN), Tokushima University, 3-18-15 Kuramoto, Tokushima, 770-8503, Japan.
Keiji UchiyamaDivision of Molecular Neurobiology, The Institute for Enzyme Research (KOSOKEN), Tokushima University, 3-18-15 Kuramoto, Tokushima, 770-8503, Japan.
Kentaro MasujinInfluenza and Prion Disease Research Center, National Institute of Animal Health (NIAH), National Agriculture and Food Research Organization (NARO), 3-1-5 Kannondai, Tsukuba, Ibaraki, 305-0856, Japan.
Hitomi WatanabeLaboratory of Integrative Biological Science, Institute for Frontier Life and Medical Sciences, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
Gen KondohLaboratory of Integrative Biological Science, Institute for Frontier Life and Medical Sciences, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
Suehiro SakaguchiDivision of Molecular Neurobiology, The Institute for Enzyme Research (KOSOKEN), Tokushima University, 3-18-15 Kuramoto, Tokushima, 770-8503, Japan. sakaguchi@tokushima-u.ac.jp.ORCID http://orcid.org/0000-0002-8824-3124
Tokushima University · JPKyoto University · JPNational Agriculture and Food Research Organization · JPUniversity of Occupational and Environmental Health Japan · JP

Funding

JSPS KAKENHI 26293212MEXT KAKENHI 15H01560MEXT KAKENHI 17H05701
6 · The paper itself

Abstract

Conformational conversion of the cellular isoform of prion protein, designated PrP

Indexed as

AnimalsLysineMice, TransgenicPrion DiseasesPrion ProteinsPrionsPrPC ProteinsSequence DeletionLysinePrion ProteinsPrionsPrPC ProteinsNeurodegenerationOctapeptide repeatPolybasic regionPrionPrion proteinTransgenic mice

Identifiers

PMID31707632
OpenAlexW2986896861

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.