Evidence map›Paper›PMID 31707593›Full record

ArticleGeroScience2019

Polygenic risk score for disability and insights into disability-related molecular mechanisms.

Alexander M Kulminski, Chansuk Kang, Stanislav A Kolpakov, Yury Loika, Alireza Nazarian, Anatoliy I Yashin, Eric Stallard, Irina Culminskaya

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 85% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Alexander M KulminskiBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, 27708-0408, USA. Alexander.Kulminski@duke.edu.ORCID http://orcid.org/0000-0002-0205-8228
Chansuk KangBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, 27708-0408, USA.
Stanislav A KolpakovBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, 27708-0408, USA.
Yury LoikaBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, 27708-0408, USA.
Alireza NazarianBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, 27708-0408, USA.
Anatoliy I YashinBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, 27708-0408, USA.
Eric StallardBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, 27708-0408, USA.
Irina CulminskayaBiodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, 27708-0408, USA.
Social Science Research Council · US

Funding

STALLARD Admin Supp: Predicting Future Care Needs and Costs for Individual Medicare Enrollees with Incident Suspected Alzheimer's DiseaseP30AG034424 · NIA · DUKE UNIVERSITY · PI Herman Pontzer · 2009 to 2026
$12.2M
Relationships among Genetic Regulators of Aging Health and LifespanP01AG043352 · NIA · DUKE UNIVERSITY · PI YASHIN, ANATOLIY I · 2014 to 2018
$8.7M
ApoE2 and protective molecular signatures in Alzheimer's disease and agingR01AG061853 · NIA · DUKE UNIVERSITY · PI KULMINSKI, ALEXANDER M · 2018 to 2022
$3.9M
YASHIN Admin Supp: Time Trends in Alzheimer's Disease: Addressing the Changing Role of Risk Factors and Instrument ValidityR01AG046860 · NIA · DUKE UNIVERSITY · PI YASHIN, ANATOLIY I · 2014 to 2018
$3.1M
Molecular signatures of health and life span disparities between whites and African-Americans in the APOE regionR01AG047310 · NIA · DUKE UNIVERSITY · PI KULMINSKI, ALEXANDER M · 2015 to 2019
$2.5M
Explanations of Racial Disparities in Active LifeR03HD050374 · NICHD · PRINCETON UNIVERSITY · PI LYNCH, SCOTT M · 2005 to 2006
$156k
NIA NIH HHS P01 AG043352NIA NIH HHS P30 AG034424NIA NIH HHS R01 AG046860NIA NIH HHS R01 AG047310NIA NIH HHS R01 AG061853NICHD NIH HHS R03 HD050374
6 · The paper itself

Abstract

Late life disability is a highly devastating condition affecting 20% or more of persons aged 65 years and older in the USA; it is an important determinant of acute medical and long-term care costs which represent a growing burden on national economies. Disability is a multifactorial trait that contributes substantially to decline of health/wellbeing. Accordingly, gaining insights into the genetics of disability could help in identifying molecular mechanisms of this devastating condition and age-related processes contributing to a large fraction of specific geriatric conditions, concordantly with geroscience. We performed a genome-wide association study of disability in a sample of 24,068 subjects from five studies with 12,550 disabled individuals. We identified 30 promising disability-associated polymorphisms in 19 loci at p < 10

Indexed as

Disability EvaluationPolymorphism, Single NucleotideAgedAgingAllelesFemaleGenome-Wide Association StudyGenotypeHumansMaleMiddle AgedMultifactorial InheritancePhenotypeRisk FactorsBiological functionDisabilityGenetic architecturePolygenic risk score

Identifiers

PMID31707593
PMCPMC6925082
OpenAlexW2988092241

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.