ArticleEuropean journal of applied physiology2020
Hyperinsulinaemia and hyperglycaemia promote glucose utilization and storage during low- and high-intensity exercise.
Article in European journal of applied physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 6 citations in OpenAlex.
- Exercise-Induced Improvements in Postprandial Glucose Response Are Blunted by Pre-Exercise Hyperglycemia: A Randomized Crossover Trial in Healthy Individuals.Frontiers in endocrinology · 2020Trial
- Carbohydrate Ingestion on Exercise Metabolism and Physical Performance.Endocrine reviews · 2026Review
- The effect of the menstrual cycle and hyperglycaemia on hormonal and metabolic responses during exercise.European journal of applied physiology · 2021Article
- Exogenous carbohydrate and regulation of muscle carbohydrate utilisation during exercise.European journal of applied physiology · 2021Review
- Observational
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe effect of hyperglycaemia with and without additional insulin was explored at a low and high intensity of exercise (40% vs 70% VO
methodsEight healthy trained males were exercised for 120 min in four trials, twice at 40% VO
resultsHyperglycaemia significantly elevated plasma insulin concentration (p < 0.001), although no difference was observed between the exercise intensities. Insulin infusion during both mild and severe exercise resulted in increased insulin concentrations (p < 0.01) and GUR (p < 0.01) compared with glucose (40%GI by 25.2%; 70%GI by 26.2%), but failed to significantly affect carbohydrate, fat and protein oxidation. NOGD was significantly higher for GI trials at both intensities (p < 0.05) with storage occurring during both lower intensities (62.7 ± 19.6 g 40%GI; 127 ± 20.7 g 40%GI) and 70%GI (29.0 ± 20.0 g). Muscle glycogen concentrations were significantly depleted from rest (p < 0.01) after all four trials.
conclusionHyperinsulinaemia in the presence of hyperglycaemia during both low- and high-intensity exercise promotes GUR and NOGD, but does not significantly affect substrate oxidation.
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Registered trials
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