Evidence map›Paper›PMID 31707377›Full record

ArticleJournal of neonatal-perinatal medicine2020

Early fortification of enteral feedings for infants <1250 grams birth weight receiving a human milk diet including human milk based fortifier.

Robert Huston, Martin Lee, Evelyn Rider, Melissa Stawarz, Dawn Hedstrom, Melissa Pence, Vera Chan, Jessica Chambers, Stefanie Rogers, Nadine Sager and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neonatal-perinatal medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 4 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 4 syntheses or guidelines pooled it, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Robert HustonNorthwest Newborn Specialists, PC and Pediatrix Medical Group, Portland, OR, USA.
Martin LeeProlacta Bioscience, Duarte, CA, USA.
Evelyn RiderProvidence Alaska Medical Center, Anchorage, AK, USA.
Melissa StawarzProvidence St. Vincent Medical Center, Portland, OR, USA.
Dawn HedstromBillings Clinic, Billings, MT, USA.
Melissa PenceSalem Health Hospitals and Clinics, Salem, OR, USA.
Vera ChanProlacta Bioscience, Duarte, CA, USA.
Jessica ChambersProvidence Alaska Medical Center, Anchorage, AK, USA.
Stefanie RogersProvidence St. Vincent Medical Center, Portland, OR, USA.
Nadine SagerBillings Clinic, Billings, MT, USA.
Laurie RiemannBillings Clinic, Billings, MT, USA.
Howard CohenSalem Health Hospitals and Clinics, Salem, OR, USA.
Billings Clinic · USProvidence Alaska Medical Center · USProvidence St. Vincent Medical Center · USSalem Hospital · USSeattle Reproductive Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAn exclusive human milk diet (EHM) including fortification with a human milk-based fortifier has been shown to decrease the occurrence of necrotizing enterocolitis (NEC) but growth velocity may be less for infants receiving EHM compared to a bovine diet.

objectiveThe objective of this study was to determine if growth is improved by earlier fortification of breast milk for preterm infants supported with a human milk based fortifier. STUDY

designA multi-center retrospective cohort study of the outcomes of infants of 500- 1250 g birth weight whose breast milk feedings were fortified at >60 mL/kg/day (late) versus <60 mL/kg/day (early) of enteral feeding volume.

resultsMedian±IQR range for gestational age (27.6±3.4 vs 27.0±2.9 weeks, p = 0.03) and chronic lung disease (CLD: 42.6 vs 27.6%, p = 0.008) were higher, and weight gain (12.9±2.6 vs 13.3±2.6 g/kg/day, p = 0.03) was lower in the late (N = 102) vs the early (N = 292) group. Adjusted multiple linear regression analysis found that early fortification was associated with improved growth velocity for weight (p = 0.007) and head circumference (HC) (p = 0.021) and less negative changes in z-scores for weight (p = 0.022) and HC (p = 0.046) from birth to discharge. Adjusted multiple logistic regression found that early fortification was associated with decreased occurrence of CLD (p = 0.004). No other outcomes, including NEC, were associated with early versus late fortification.

conclusionThe study results suggested that early HM fortification appears to positively affect growth for infants whose human milk feedings are fortified with a human milk based fortifier without adverse effects. The incidence of CLD was also reduced in the early fortification group.

Indexed as

Food, FortifiedMilk, HumanWeight GainChronic DiseaseEnteral NutritionEnterocolitis, NecrotizingFemaleGestational AgeGrowthHeadHumansInfant, Extremely Low Birth WeightInfant, Extremely PrematureInfant, NewbornInfant, PrematureInfant, Very Low Birth Weightclinical outcomesfortificationgrowthHuman milk

Identifiers

PMID31707377
PMCPMC7369034
OpenAlexW2985076214

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.