Evidence map›Paper›PMID 31707334›Full record

ArticleJournal of inorganic biochemistry2020

Aluminum-induced generation of lipopolysaccharide (LPS) from the human gastrointestinal (GI)-tract microbiome-resident Bacteroides fragilis.

P N Alexandrov, J M Hill, Y Zhao, T Bond, C M Taylor, M E Percy, W Li, W J Lukiw

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of inorganic biochemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 47 citations in OpenAlex.

  1. Trial
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  6. Frontiers in microbiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 4 countries.

P N AlexandrovRussian Academy of Medical Science, Moscow 113152, Russian Federation.
J M HillLSU Neuroscience Center, LSU Health Sciences Center, New Orleans, LA 70112, USA; Department of Microbiology, Immunology and Parasitology, LSUHSC, New Orleans, LA 70112, USA.
Y ZhaoLSU Neuroscience Center, LSU Health Sciences Center, New Orleans, LA 70112, USA; Department of Cell Biology and Anatomy, LSU Health Sciences Center, New Orleans, LA 70112, USA.
T BondLSU Neuroscience Center, LSU Health Sciences Center, New Orleans, LA 70112, USA.
C M TaylorDepartment of Microbiology, Immunology and Parasitology, LSUHSC, New Orleans, LA 70112, USA.
M E PercyDepartments of Neurogenetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
W LiLSU Neuroscience Center, LSU Health Sciences Center, New Orleans, LA 70112, USA; Department of Pharmacology, Jiangxi University of TCM, Nanchang, Jiangxi 330004, China.
W J LukiwRussian Academy of Medical Science, Moscow 113152, Russian Federation; LSU Neuroscience Center, LSU Health Sciences Center, New Orleans, LA 70112, USA; Department of Neurology, LSU Health Sciences Center, New Orleans, LA 70112, USA; Department of Ophthalmology, LSU Health Sciences Center, New Orleans, LA 70112, USA. Electronic address: wlukiw@lsuhsc.edu.
Louisiana State University Health Sciences Center New Orleans · USJiangxi University of Traditional Chinese Medicine · CNRussian Academy of Sciences · RUUniversity of Toronto · CA

Funding

OCULAR HSV: LATENCY, REACTIVATION, &RECURRENCER01EY006311 · NEI · LSU HEALTH SCIENCES CENTER · PI HILL, JAMES M · 1985 to 2012
$5.3M
microRNA (miRNA) signaling in Alzheimer's disease(AD)R01AG038834 · NIA · LSU HEALTH SCIENCES CENTER · PI BAZAN, NICOLAS G. · 2011 to 2020
$3.3M
Gene Expression in Alzheimer's DiseaseR01AG018031 · NIA · LSU HEALTH SCIENCES CENTER · PI LUKIW, WALTER J · 2001 to 2006
$1.4M
NEI NIH HHS R01 EY006311NIA NIH HHS R01 AG018031NIA NIH HHS R01 AG038834
6 · The paper itself

Abstract

Gram-negative bacteria of the human gastrointestinal (GI) tract microbiome: (i) are capable of generating a broad-spectrum of highly neurotoxic, pro-inflammatory and potentially pathogenic molecules; and (ii) these include a highly immunogenic class of amphipathic surface glycolipids known as lipopolysaccharide (LPS). Bacteroides fragilis (B. fragilis), a commensal, Gram negative, non-motile, non-spore forming obligatory anaerobic bacillus, and one of the most abundant bacteria found in the human GI tract, produces a particularly pro-inflammatory and neurotoxic LPS (BF-LPS). BF-LPS: (i) is known to be secreted from the B. fragilis outer membrane into the external-medium; (ii) can damage biophysiological barriers via cleavage of zonula adherens cell-cell adhesion proteins, thereby disrupting both the GI-tract barrier and the blood-brain barrier (BBB); (iii) is able to transit GI-tract barriers into the systemic circulation and cross the BBB into the human CNS; and (iv) accumulates within CNS neurons in neurodegenerative disorders such as Alzheimer's disease (AD). This short communication provides evidence that the incubation of B. fragilis with aluminum sulfate [Al

Indexed as

Alum CompoundsBacteroides fragilisLipopolysaccharidesAlum Compoundsaluminum sulfateLipopolysaccharidesAluminumAlzheimer's diseaseBF-LPSB. fragilisDysbiosisFragilysinInflammationLipopolysaccharideMicrobiome

Identifiers

PMID31707334
PMCPMC7409391
OpenAlexW2982095708

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.