ArticleComprehensive psychiatry2020
Longitudinal population subgroups of CRP and risk of depression in the ALSPAC birth cohort.
Article in Comprehensive psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Cancer-related inflammation and depressive symptoms: Systematic review and meta-analysis.Cancer · 2022Pooled it
- Inflammation and depression in young people: a systematic review and proposed inflammatory pathways.Molecular psychiatry · 2022Pooled it
- Investigating the prospective associations of childhood sleep problems with persistent depression in emerging adulthood: the mediating role of inflammation.European child & adolescent psychiatry · 2026Article
- Higher Lipopolysaccharide Levels Are Linked to Less Anhedonia and Lower Severity of Major Depressive Disorder.Brain sciences · 2026Article
- Examining whether inflammation mediates effects of genetic risk and trauma on psychopathology.BJPsych open · 2025Article
- Individual and integrated indexes of inflammation predicting the risks of mental disorders - statistical analysis and artificial neural network.BMC psychiatry · 2025Article
- Associations between IL-6 and trajectories of depressive symptoms across the life course: Evidence from ALSPAC and UK Biobank cohorts.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- The correlation between systemic immune-inflammation index and major depression in patients with depression.Frontiers in psychiatry · 2025Article
- Phenome-wide investigation of bidirectional causal relationships between major depressive disorder and common human diseases.Translational psychiatry · 2024Article
- Bidirectional relationship between C-reactive protein and depressive symptoms considering cumulative effect among Chinese middle-aged and older adults.Frontiers in psychiatry · 2024Article
- Assessing the Evidence for Causal Associations Between Body Mass Index, C-Reactive Protein, Depression, and Reported Trauma Using Mendelian Randomization.Biological psychiatry global open science · 2023Article
- Early-life inflammatory markers and subsequent psychotic and depressive episodes between 10 to 28 years of age.Brain, behavior, & immunity - health · 2022Article
- Article
- C-Reactive Protein as a Biomarker for Major Depressive Disorder?International journal of molecular sciences · 2022Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundMeta-analyses confirm increased circulating C-reactive protein (CRP) levels in depression. Longitudinal studies have linked one-off measurements of CRP at baseline with increased risk of developing depressive symptoms subsequently at follow-up, but studies with repeat CRP measures from the same individuals are scarce.
methodsWe have examined whether longitudinal patterns of inflammation, based on three CRP measurements from childhood to early-adulthood, are associated with the risk of depression in early-adulthood in the Avon Longitudinal Study of Parents and Children, a prospective birth cohort.
resultsUsing Gaussian mixture modelling of available CRP data from age 9, 15 and 18 years, we identified four population clusters/sub-groups reflecting different longitudinal patterns of CRP: persistently low (N=463, 29.5%); persistently high (N=371, 24%); decreasing (N=360, 23%); increasing (N=367, 23.5%). The increasing group showed a steep increase in CRP levels between adolescence and early-adulthood. Participants in this group had a higher risk of moderate/severe depression at age 18 years, compared with those with persistently low CRP; adjusted odds ratio (OR)=3.78 (95% Confidence Interval (CI), 1.46-9.81; p=0.006). The odds of moderate/severe depression were also increased for the persistently high CRP group, but this was not statistically significant; OR=2.54 (95% CI, 0.90-7.16). LIMITATIONS: Repeat CRP measures were available for a subset, who may not be representative of all cohort participants.
conclusionsThe results suggest that an increasing pattern of inflammation from adolescence to early-adulthood is associated with risk of depression in early-adulthood.
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