Evidence map›Paper›PMID 31707052›Full record

ReviewAdvanced drug delivery reviews2019

Nanotechnology in regenerative ophthalmology.

Fitsum Feleke Sahle, Sangyoon Kim, Kumar Kulldeep Niloy, Faiza Tahia, Cameron V Fili, Emily Cooper, David J Hamilton, Tao L Lowe

Open access · greenAbstract readReview
In one paragraph

Review in Advanced drug delivery reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Nanotechnology-Based Treatment for Ophthalmic Diseases.International journal of nanomedicine · 2026
    Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Annexin A1 in the nervous and ocular systems.Neural regeneration research · 2024
    Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Fitsum Feleke SahleDepartment of Pharmaceutical Sciences, University of Tennessee Health Sciences Center, Memphis, TN 38163, USA.
Sangyoon KimDepartment of Pharmaceutical Sciences, University of Tennessee Health Sciences Center, Memphis, TN 38163, USA.
Kumar Kulldeep NiloyDepartment of Pharmaceutical Sciences, University of Tennessee Health Sciences Center, Memphis, TN 38163, USA.
Faiza TahiaDepartment of Pharmaceutical Sciences, University of Tennessee Health Sciences Center, Memphis, TN 38163, USA.
Cameron V FiliDepartment of Comparative Medicine, University of Tennessee Health Sciences Center, Memphis, TN 38163, USA.
Emily CooperDepartment of Pharmaceutical Sciences, University of Tennessee Health Sciences Center, Memphis, TN 38163, USA.
David J HamiltonDepartment of Comparative Medicine, University of Tennessee Health Sciences Center, Memphis, TN 38163, USA.
Tao L LoweDepartment of Pharmaceutical Sciences, University of Tennessee Health Sciences Center, Memphis, TN 38163, USA. Electronic address: tlowe4@uthsc.edu.
University of Tennessee Health Science Center · US

Funding

Nanogels for Drug Delivery across the BRB to Treat Diabetic RetinopathyR01EY023853 · NEI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI LOWE, TAO L · 2016 to 2020
$1.9M
NEI NIH HHS R01 EY023853
6 · The paper itself

Abstract

In recent years, regenerative medicine is gaining momentum and is giving hopes for restoring function of diseased, damaged, and aged tissues and organs and nanotechnology is serving as a catalyst. In the ophthalmology field, various types of allogenic and autologous stem cells have been investigated to treat some ocular diseases due to age-related macular degeneration, glaucoma, retinitis pigmentosa, diabetic retinopathy, and corneal and lens traumas. Nanomaterials have been utilized directly as nanoscaffolds for these stem cells to promote their adhesion, proliferation and differentiation or indirectly as vectors for various genes, tissue growth factors, cytokines and immunosuppressants to facilitate cell reprogramming or ocular tissue regeneration. In this review, we reviewed various nanomaterials used for retina, cornea, and lens regenerations, and discussed the current status and future perspectives of nanotechnology in tracking cells in the eye and personalized regenerative ophthalmology. The purpose of this review is to provide comprehensive and timely insights on the emerging field of nanotechnology for ocular tissue engineering and regeneration.

Indexed as

NanotechnologyOphthalmologyDrug Delivery SystemsHumansNanostructuresNerve RegenerationNeuroprotective AgentsRegenerative MedicineTissue EngineeringNeuroprotective AgentsCell reprogrammingElectrospun nanofibersImmunomodulatorsNanoscaffoldsNanotopographyOcular regenerationSelf-assembled peptidesStem cells

Identifiers

PMID31707052
PMCPMC7474549
OpenAlexW2987164780

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.