Evidence map›Paper›PMID 31707036›Full record

ArticlePharmacological research2020

SKA-31, an activator of Ca

Cini Mathew John, Rayan Khaddaj Mallat, Ramesh C Mishra, Grace George, Vikrant Singh, Jeannine D Turnbull, Channakeshava S Umeshappa, Dylan J Kendrick, Taeyeob Kim, Fazlin M Fauzi and 4 more

Open access · greenAbstract read
In one paragraph

Article in Pharmacological research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Review
  3. Cellular and molecular mechanisms underlying cardiovascular aging.Cellular & molecular biology letters · 2025
    Review
  4. How to measure and model cardiovascular aging.Cardiovascular research · 2025
    Review
  5. Article
  6. Review
  7. Administration of the KFrontiers in pharmacology · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. KJournal of neuroscience research · 2023
    Review
  12. Impact of aging on vascular ion channels: perspectives and knowledge gaps across major organ systems.American journal of physiology. Heart and circulatory physiology · 2023
    Review
  13. KBiomedicines · 2023
    Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 3 countries.

Cini Mathew JohnDept. of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Canada; Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Canada.
Rayan Khaddaj MallatDept. of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Canada; Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Canada.
Ramesh C MishraDept. of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Canada; Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Canada.
Grace GeorgeDept. of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Canada; Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Canada.
Vikrant SinghDept. of Pharmacology, University of California, Davis, USA.
Jeannine D TurnbullDept. of Cardiac Sciences, Cumming School of Medicine, University of Calgary, Canada; Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Canada.
Channakeshava S UmeshappaDept. of Microbiology, Immunology and Infectious Diseases, Cumming School of Medicine, University of Calgary, Canada.
Dylan J KendrickDept. of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Canada; Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Canada.
Taeyeob KimDept. of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Canada; Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Canada.
Fazlin M FauziDept. of Pharmacology and Chemistry, Universiti Teknologi MARA, Malaysia.
Frank VisserHotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Canada.
Paul W M FedakDept. of Cardiac Sciences, Cumming School of Medicine, University of Calgary, Canada; Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Canada.
Heike WulffDept. of Pharmacology, University of California, Davis, USA.
Andrew P BraunDept. of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Canada; Libin Cardiovascular Institute, Cumming School of Medicine, University of Calgary, Canada. Electronic address: abraun@ucalgary.ca.
University of Calgary · CAUniversity of California, Davis · USUniversiti Teknologi MARA · MY

Funding

Structure Assisted Design of SK Channel Selective ActivatorsR21NS101876 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI WULFF, HEIKE · 2017 to 2018
$410k
CIHR MOP-142467NINDS NIH HHS R21 NS101876
6 · The paper itself

Abstract

Aging represents an independent risk factor for the development of cardiovascular disease, and is associated with complex structural and functional alterations in the vasculature, such as endothelial dysfunction. Small- and intermediate-conductance, Ca

Indexed as

AgingAnimalsArterial PressureBenzothiazolesCells, CulturedHeartMalePotassium Channels, Calcium-ActivatedRats, Sprague-DawleyStroke VolumeVasodilationBenzothiazolesnaphtho(1,2-d)thiazol-2-ylaminePotassium Channels, Calcium-ActivatedAgingArteriesCa(2+)-activated K(+) channelsHeartImmune system

Identifiers

PMID31707036
PMCPMC6956598
OpenAlexW2987794942

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.