Evidence map›Paper›PMID 31706688›Full record

ReviewTrends in genetics : TIG2020

Evolution of Epistatic Networks and the Genetic Basis of Innate Behaviors.

Robert R H Anholt

Open access · hybridAbstract readReview
In one paragraph

Review in Trends in genetics : TIG, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Robert R H AnholtDepartment of Genetics and Biochemistry and Center for Human Genetics, Clemson University, Greenwood, SC, 29646, USA. Electronic address: ranholt@clemson.edu.
Clemson University · US

Funding

Genetics of Cocaine Sensitivity in DrosophilaU01DA041613 · NIDA · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Robert R. H Anholt, TRUDY F. MACKAY · 2017 to 2026
$4.9M
Reverse Engineering Quantitative Genetic VariationR01GM128974 · NIGMS · CLEMSON UNIVERSITY · PI ANHOLT, ROBERT R. H, MACKAY, TRUDY F. · 2018 to 2021
$1.9M
NIDA NIH HHS U01 DA041613NIGMS NIH HHS R01 GM128974
6 · The paper itself

Abstract

Instinctive behaviors are genetically programmed behaviors that occur independent of experience. How genetic programs that give rise to the manifestation of such behaviors evolve remains an unresolved question. I propose that evolution of species-specific innate behaviors is accomplished through progressive modifications of pre-existing genetic networks composed of allelic variants. I hypothesize that changes in frequencies of one or more constituent allelic variants within the network leads to changes in gene network connectivity and the emergence of a reorganized network that can support the emergence of a novel behavioral phenotype and becomes stabilized when key allelic variants are driven to fixation.

Indexed as

Biological EvolutionEvolution, MolecularInstinctAllelesAnimalsEpistasis, GeneticGene Regulatory NetworksGenetic VariationMutationPhenotypeallelic variantsbehavioral geneticsgene expressionpleiotropypositive selectiontranscriptome

Identifiers

PMID31706688
PMCPMC6925314
OpenAlexW2986596007

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.