Trial reportThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2020
Neurocognitive Effects of Combined Electroconvulsive Therapy (ECT) and Venlafaxine in Geriatric Depression: Phase 1 of the PRIDE Study.
Trial report in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Psychiatric Association of Türkiye Mood Disorders Section Depression Treatment Guideline - III: Treatment Approach for Depression Subtypes and Special Groups, Psychotherapies, and Psychosocial Interventions.Turk psikiyatri dergisi = Turkish journal of psychiatry · 2026Guideline
- Comparing the Neurocognitive Effects of Right Unilateral Ultra-Brief Pulse Electroconvulsive Therapy and Magnetic Seizure Therapy for the Treatment of Major Depressive Episode.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Trial
- Longitudinal Neurocognitive Effects of Combined Electroconvulsive Therapy (ECT) and Pharmacotherapy in Major Depressive Disorder in Older Adults: Phase 2 of the PRIDE Study.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2022Trial
- Electroconvulsive Therapy Pulse Amplitude and Clinical Outcomes.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2021Trial
- Trial
- Comparative efficacy and cognitive function of magnetic seizure therapy and electroconvulsive therapy for major depressive disorder: a systematic review and meta-analysis of randomized controlled trials.Frontiers in psychiatry · 2026Review
- New insights into the mechanisms of electroconvulsive therapy in treatment-resistant depression.Frontiers in psychiatry · 2025Review
- Electroconvulsive therapy and cognitive performance from the Global ECT MRI Research Collaboration.Journal of psychiatric research · 2024Article
- Recent Advances in the Treatment of Treatment-Resistant Depression: A Narrative Review of Literature Published from 2018 to 2023.Current psychiatry reports · 2024Review
- Article
- How electroconvulsive therapy works in the treatment of depression: is it the seizure, the electricity, or both?Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Biological factors influencing depression in later life: role of aging processes and treatment implications.Translational psychiatry · 2023Review
- Recent advances in electroconvulsive therapy in clinical practice and research.Faculty reviews · 2023Review
- The Use of ECT in the Elderly-Looking Beyond Depression.Current psychiatry reports · 2022Review
- The Effects of Baseline Impaired Global Cognitive Function on the Efficacy and Cognitive Effects of Electroconvulsive Therapy in Geriatric Patients: A Retrospective Cohort Study.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2022Article
- Ictal Theta Power as an Electroconvulsive Therapy Safety Biomarker: A Pilot Study.The journal of ECT · 2022Article
- ECT-induced cognitive side effects are associated with hippocampal enlargement.Translational psychiatry · 2021Article
- The Neurobiological Basis of Cognitive Side Effects of Electroconvulsive Therapy: A Systematic Review.Brain sciences · 2021Review
- Understanding Vulnerability to Late-Life Suicide.Current psychiatry reports · 2021Review
- Clinical Neuropsychological Evaluation in Older Adults With Major Depressive Disorder.Current psychiatry reports · 2021Review
Corrections and comments
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Authors and funding
29 authors at 10 institutions in 1 country.
Funding
Abstract
objectiveThere is limited information regarding the tolerability of electroconvulsive therapy (ECT) combined with pharmacotherapy in elderly adults with major depressive disorder (MDD). Addressing this gap, we report acute neurocognitive outcomes from Phase 1 of the Prolonging Remission in Depressed Elderly (PRIDE) study.
methodsElderly adults (age ≥60) with MDD received an acute course of 6 times seizure threshold right unilateral ultrabrief pulse (RUL-UB) ECT. Venlafaxine was initiated during the first treatment week and continued throughout the study. A comprehensive neurocognitive battery was administered at baseline and 72 hours following the last ECT session. Statistical significance was defined as a two-sided p-value of less than 0.05.
resultsA total of 240 elderly adults were enrolled. Neurocognitive performance acutely declined post ECT on measures of psychomotor and verbal processing speed, autobiographical memory consistency, short-term verbal recall and recognition of learned words, phonemic fluency, and complex visual scanning/cognitive flexibility. The magnitude of change from baseline to end for most neurocognitive measures was modest.
conclusionThis is the first study to characterize the neurocognitive effects of combined RUL-UB ECT and venlafaxine in elderly adults with MDD and provides new evidence for the tolerability of RUL-UB ECT in an elderly sample. Of the cognitive domains assessed, only phonemic fluency, complex visual scanning, and cognitive flexibility qualitatively declined from low average to mildly impaired. While some acute changes in neurocognitive performance were statistically significant, the majority of the indices as based on the effect sizes remained relatively stable.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.