ArticleVeterinary research2019
Evolution of infectious bronchitis virus in the field after homologous vaccination introduction.
Article in Veterinary research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- Emergence of infectious bronchitis virus genotype GI-24 and GI-16 along with predominant circulation of genotype GI-1 in commercial poultry in Bangladesh.Poultry science · 2026Article
- Vaccination-driven evolution of infectious bronchitis virus in Korea: implication for the control of other coronavirus infections.Frontiers in veterinary science · 2026Review
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- Reconstruction of Avian Reovirus History and Dispersal Patterns: A Phylodynamic Study.Viruses · 2024Article
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- Towards a Safer Future: Enhancing Vaccine Development to Combat Animal Coronaviruses.Vaccines · 2024Review
- The efficacy of simultaneous successive classic and variant infectious bronchitis virus vaccines versus circulating variant II Egyptian field virus.Open veterinary journal · 2024Article
- Seroprevalence and molecular characterisation of infectious bronchitis virus (IBV) in broiler farms in Sabah, Malaysia.Veterinary medicine and science · 2023Article
- Receptor binding motif surrounding sites in the spike 1 protein of infectious bronchitis virus have high susceptibility to mutation related to selective pressure.Journal of veterinary science · 2023Article
- Genetic analysis of infectious bronchitis virus (IBV) in vaccinated poultry populations over a period of 10 years.Avian pathology : journal of the W.V.P.A · 2023Article
- When Everything Becomes Bigger: Big Data for Big Poultry Production.Animals : an open access journal from MDPI · 2023Review
- Global Emergence of Infectious Bronchitis Virus Variants: Evolution, Immunity, and Vaccination Challenges.Transboundary and emerging diseases · 2023Review
- Comparative Genetic Features ofArchives of Razi Institute · 2022Article
- Article
- Modeling pandemic to endemic patterns of SARS-CoV-2 transmission using parameters estimated from animal model data.PNAS nexus · 2022Article
- The N1038S Substitution andFrontiers in microbiology · 2022Article
- Evolution of pathogen tolerance and emerging infections: A missing experimental paradigm.eLife · 2021Review
- Plant-Derived Antimicrobial Peptides as Potential Antiviral Agents in Systemic Viral Infections.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Platforms for Personalized Polytherapeutics Discovery in COVID-19.Journal of molecular biology · 2021Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Despite the fact that vaccine resistance has been typically considered a rare phenomenon, some episodes of vaccine failure have been reported with increasing frequency in intensively-raised livestock. Infectious bronchitis virus (IBV) is a widespread avian coronavirus, whose control relies mainly on extensive vaccine administration. Unfortunately, the continuous emergence of new vaccine-immunity escaping variants prompts the development of new vaccines. In the present work, a molecular epidemiology study was performed to evaluate the potential role of homologous vaccination in driving IBV evolution. This was undertaken by assessing IBV viral RNA sequences from the ORF encoding the S1 portion of viral surface glycoprotein (S) before and after the introduction of a new live vaccine on broiler farms in northern-Italy. The results of several biostatistics analyses consistently demonstrate the presence of a higher pressure in the post-vaccination period. Natural selection was detected essentially on sites located on the protein surface, within or nearby domains involved in viral attachment or related functions. This evidence strongly supports the action of vaccine-induced immunity in conditioning viral evolution, potentially leading to the emergence of new vaccine-escape variants. The great plasticity of rapidly-evolving RNA-viruses in response to human intervention, which extends beyond the poultry industry, is demonstrated, claiming further attention due to their relevance for animal and especially human health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.