Evidence map›Paper›PMID 31706326›Full record

ArticleJournal of translational medicine2019

Infected chronic ischemic wound topically treated with a multi-strain probiotic formulation: a novel tailored treatment strategy.

Salvatore Venosi, Giancarlo Ceccarelli, Massimiliano de Angelis, Luca Laghi, Laura Bianchi, Ombretta Martinelli, Debora Maruca, Eugenio Nelson Cavallari, Fabrizia Toscanella, Paolo Vassalini and 3 more

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 33 citations in OpenAlex.

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  3. The dual role of the microbiome in chronic wound management.Cell communication and signaling : CCS · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Salvatore VenosiDepartment of Cardio-Thoraco-Vascular, Surgery and Transplants, University of Rome Sapienza, Rome, Italy.
Giancarlo CeccarelliDepartment of Public Health and Infectious Diseases, University of Rome Sapienza, Viale del Policlinico 155, Rome, Italy. gi.ceccarelli@policlinicoumberto1.it.ORCID 0000-0001-5921-3180
Massimiliano de AngelisDepartment of Public Health and Infectious Diseases, University of Rome Sapienza, Viale del Policlinico 155, Rome, Italy.
Luca LaghiDepartment of Agri-Food Science and Technology, University of Bologna, Bologna, Italy.
Laura BianchiFunctional Proteomic Laboratory, Department of Life Sciences, University of Siena, Siena, Italy.
Ombretta MartinelliDepartment of Cardio-Thoraco-Vascular, Surgery and Transplants, University of Rome Sapienza, Rome, Italy.
Debora MarucaDepartment of Cardio-Thoraco-Vascular, Surgery and Transplants, University of Rome Sapienza, Rome, Italy.
Eugenio Nelson CavallariDepartment of Public Health and Infectious Diseases, University of Rome Sapienza, Viale del Policlinico 155, Rome, Italy.
Fabrizia ToscanellaDiabetic Foot Center, Istituto Nazionale Ricovero e Cura Anziani (INRCA), Ancona, Italy.
Paolo VassaliniDepartment of Public Health and Infectious Diseases, University of Rome Sapienza, Viale del Policlinico 155, Rome, Italy.
Vito TrinchieriDepartment of Public Health and Infectious Diseases, University of Rome Sapienza, Viale del Policlinico 155, Rome, Italy.
Alessandra OlivaDepartment of Public Health and Infectious Diseases, University of Rome Sapienza, Viale del Policlinico 155, Rome, Italy.
Gabriella d'EttorreDepartment of Public Health and Infectious Diseases, University of Rome Sapienza, Viale del Policlinico 155, Rome, Italy.
Policlinico Umberto I · ITSapienza University of Rome · ITIstituto Nazionale di Riposo e Cura per Anziani · ITUniversity of Bologna · ITUniversity of Siena · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA wide debate is ongoing regarding the role of cutaneous dysbiosis in the pathogenesis and evolution of difficult-to-treat chronic wounds. Nowadays, probiotic treatment considered as an useful tool to counteract dysbiosis but the evidence in regard to their therapeutic use in the setting of difficult-to-treat cutaneous ulcers is still poor.

aimCLINICAL REPORT: An 83-year-old woman suffering a critical limb ischemia and an infected difficult-to-treat ulcerated cutaneous lesion of the right leg, was complementary treated with local application of a mixture of probiotic bacteria.

methodsMicrobiological and metabolomic analysis were conducted on wound swabs obtained before and after bacteriotherapy.

resultsDuring the treatment course, a progressive healing of the lesion was observed with microbiological resolution of the polymicrobial infection of the wound. Metabolomic analysis showed a significant difference in the local concentration of propionate, 2-hydroxyisovalerate, 2-oxoisocaproate, 2,3-butanediol, putrescine, thymine, and trimethylamine before and after bacteriotherapy.

conclusionThe microbiological and metabolomic results seem to confirm the usefulness of complementary probiotic treatment in difficult-to-treat infected wounds. Further investigations are needed to confirm these preliminary findings.

Indexed as

Administration, TopicalAged, 80 and overChronic DiseaseFemaleHumansIschemiaLegMetabolomeProbioticsSkinSkin UlcerTranslational Research, BiomedicalWound HealingWound InfectionAntimicrobial resistanceBacteriotherapyMetabolomicTopical probioticWoundWound careWound healing

Identifiers

PMID31706326
PMCPMC6842486
OpenAlexW2983687044

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.