ArticleThe Journal of cell biology1988
Incorporation of a product of mevalonic acid metabolism into proteins of Chinese hamster ovary cell nuclei.
Article in The Journal of cell biology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 179 citations in OpenAlex.
- Lamin post-translational modifications: emerging toggles of nuclear organization and function.Trends in biochemical sciences · 2021Review
- Novel route to chaetomellic acid A and analogues: serendipitous discovery of a more competent FTase inhibitor.Bioorganic & medicinal chemistry · 2013Article
- Protein farnesylation and disease.Journal of inherited metabolic disease · 2012Review
- An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria.Human molecular genetics · 2010Article
- The posttranslational processing of prelamin A and disease.Annual review of genomics and human genetics · 2009Review
- Accessibility and conformational coupling in serotonin transporter predicted internal domains.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Oligomerization of serotonin transporter and its functional consequences.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Basic fibroblast growth factor does not prevent heparan sulphate proteoglycan catabolism in intact cells, but it alters the distribution of the glycosaminoglycan degradation products.The Biochemical journal · 1999Article
- Manumycin and gliotoxin derivative KT7595 block Ras farnesylation and cell growth but do not disturb lamin farnesylation and localization in human tumour cells.British journal of cancer · 1997Article
- Effect of lovastatin alone and as an adjuvant chemotherapeutic agent on hepatoma tissue culture-4 cell growth.Annals of surgical oncology · 1995Article
- Modulation of the mevalonate pathway and cell growth by pravastatin and d-limonene in a human hepatoma cell line (Hep G2).British journal of cancer · 1994Article
- The role of CaaX-dependent modifications in membrane association of Xenopus nuclear lamin B3 during meiosis and the fate of B3 in transfected mitotic cells.The Journal of cell biology · 1993Article
- Stepwise reassembly of the nuclear envelope at the end of mitosis.The Journal of cell biology · 1993Article
- Mapping of multiple mouse loci related to the farnesyl pyrophosphate synthetase gene.Mammalian genome : official journal of the International Mammalian Genome Society · 1993Article
- The gene structure of Xenopus nuclear lamin A: a model for the evolution of A-type from B-type lamins by exon shuffling.Chromosoma · 1992Article
- Nucleoplasmic localization of prelamin A: implications for prenylation-dependent lamin A assembly into the nuclear lamina.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Enzymatic modification of proteins with a geranylgeranyl isoprenoid.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Characterization of A 54-kD protein of the inner nuclear membrane: evidence for cell cycle-dependent interaction with the nuclear lamina.The Journal of cell biology · 1991Article
- Relationship among methylation, isoprenylation, and GTP binding in 21- to 23-kDa proteins of neuroblastoma.Cellular and molecular neurobiology · 1991Article
- Disassembly of in vitro formed lamin head-to-tail polymers by CDC2 kinase.The EMBO journal · 1991Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have examined the nuclear localization of isoprenylated proteins in CHO-K1 cells labeled with [14C]mevalonate. Nuclear proteins of 68, 70, and 74 kD, posttranslationally modified by an isoprenoid, are also components of a nuclear matrix-intermediate filament preparation from CHO cells. Furthermore, the 68-, 70-, and 74-kD isoprenylated polypeptides are immunoprecipitated from cell extracts with two different anti-lamin antisera. Based on exact two-dimensional comigration with lamin B, both from rat liver lamin and CHO nuclear matrix-intermediate filament preparations, and its immunoprecipitation with anti-lamin antisera, we conclude that the 68-kD isoprenylated protein found in nuclei from [14C]mevalonate-labeled CHO cells is lamin B. The more basic 74-kD isoprenylated nuclear protein is similar in molecular mass and isoelectric pH variants to the lamin A precursor polypeptide reported by others. Starving cells for mevalonate results in a dramatic accumulation of a polypeptide that comigrates on two-dimensional, non-equilibrium pH gradient electrophoresis (NEPHGE) gels with the 74-kD isoprenylated protein. The 70-kD isoprenylated protein, which is resolved on NEPHGE gels as being higher in molecular mass and slightly more basic than lamin B, has not yet been identified.
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