Observational studyBMC cardiovascular disorders2019
Predictors of one-year outcomes in chronic heart failure: the portrait of a middle income country.
Observational study in BMC cardiovascular disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Plasma proteomics improves risk prediction in heart failure and reveals unique biology in chronic chagas cardiomyopathy.PLoS neglected tropical diseases · 2026Article
- Rationale and design of a prospective study evaluating the prognostic value of lung ultrasound in patients with heart failure in primary care: the EPICAP study protocol.BMC primary care · 2025Article
- Review
- Prognostic role of TAPSE to PASP ratio in outpatients with left ventricular systolic dysfunction.ESC heart failure · 2025Article
- The influence of lifestyle habits on the perception of vestibular symptoms in patients with heart failure.CoDAS · 2025Article
- American Registry of Ambulatory or acutely decompensated heart failure (AMERICCAASS Registry): First 1000 patients.Clinical cardiology · 2024Article
- Rosa dos Ventos Multicenter Cohort Study of Patients with Reduced or Mildly Reduced Ejection Fraction Heart Failure in Brazil: Rationale and Design.Arquivos brasileiros de cardiologia · 2024Observational
- Predicting mortality and re-hospitalization for heart failure: a machine-learning and cluster analysis on frailty and comorbidity.Aging clinical and experimental research · 2023Article
- Predictive value of blood urea nitrogen in heart failure: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2023Review
- Cardiovascular Statistics - Brazil 2021.Arquivos brasileiros de cardiologia · 2022Article
- Spatial Distribution of Mortality for Heart Failure in Brazil, 1996 - 2017.Arquivos brasileiros de cardiologia · 2022Article
- Combined B-type Natriuretic Peptide as strong predictor of short-term mortality in patients after Liver Transplantation.International journal of medical sciences · 2021Article
- Cardiovascular Statistics - Brazil 2020.Arquivos brasileiros de cardiologia · 2020Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHeart failure (HF) is a major public health problem with increasing prevalence worldwide. It is associated with high mortality and poor quality of life due to recurrent and costly hospital admissions. Several studies have been conducted to describe HF risk predictors in different races, countries and health systems. Nonetheless, understanding population-specific determinants of HF outcomes remains a great challenge. We aim to evaluate predictors of 1-year survival of individuals with systolic heart failure from the GENIUS-HF cohort.
methodsWe enrolled 700 consecutive patients with systolic heart failure from the SPA outpatient clinic of the Heart Institute, a tertiary health-center in Sao Paulo, Brazil. Inclusion criteria were age between 18 and 80 years old with heart failure diagnosis of different etiologies and left ventricular ejection fraction ≤50% in the previous 2 years of enrollment on the cohort. We recorded baseline demographic and clinical characteristics and followed-up patients at 6 months intervals by telephone interview. Study data were collected and data quality assurance by the Research Electronic Data Capture tools. Time to death was studied using Cox proportional hazards models adjusted for demographic, clinical and socioeconomic variables and medication use.
resultsWe screened 2314 consecutive patients for eligibility and enrolled 700 participants. The overall mortality was 6.8% (47 patients); the composite outcome of death and hospitalization was 17.7% (123 patients) and 1% (7 patients) have been submitted to heart transplantation after one year of enrollment. After multivariate adjustment, baseline values of blood urea nitrogen (HR 1.017; CI 95% 1.008-1.027; p < 0.001), brain natriuretic peptide (HR 1.695; CI 95% 1.347-2.134; p < 0.001) and systolic blood pressure (HR 0.982;CI 95% 0.969-0.995; p = 0.008) were independently associated with death within 1 year. Kaplan Meier curves showed that ischemic patients have worse survival free of death and hospitalization compared to other etiologies.
conclusionsHigh levels of BUN and BNP and low systolic blood pressure were independent predictors of one-year overall mortality in our sample.
trial registrationCurrent Controlled Trials NTC02043431, retrospectively registered at in January 23, 2014.
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