ArticleDrug and alcohol dependence2019
Patterns of polysubstance use and simultaneous co-use in high risk young adults.
Article in Drug and alcohol dependence, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 58 citations in OpenAlex.
- Increases in striatal response to reward anticipation relate to reductions in impulsivity in women with substance use disorders.NeuroImage. Clinical · 2026Article
- Polysubstance use disorders among US adults.Molecular psychiatry · 2026Article
- An Epidemic of Complexity: Polysubstance Use Fatal Overdose Typologies Across Cook County, Illinois, Neighborhoods, 2017‒2022.American journal of public health · 2026Article
- Substance involvement profiles and mental health correlates in emerging adults: a person-centred cluster analysis.BMC public health · 2026Article
- Latent Class Analysis of Substance Use Behaviors and Associations of Class Membership With Gender Affirmation, Social Determinants of Health, and HIV Status Among Transfeminine Adults in the Eastern and Southern United States.Journal of studies on alcohol and drugs · 2026Article
- Natural language processing of patient in-session speech to predict brief motivational interviewing alcohol intervention response: an exploratory study.Alcohol and alcoholism (Oxford, Oxfordshire) · 2026Article
- The role of polysubstance use in the development, maintenance, and treatment of stimulant use disorders.Pharmacological reviews · 2026Review
- Psychopathic Traits Associate With Later Schizophrenia.Acta psychiatrica Scandinavica · 2025Article
- Daily patterns of single and poly-substance use among adolescent and young adult females: A day-level latent class analysis.Addictive behaviors · 2025Article
- Exploring the Patterns of Recreational Polysubstance Use and Executive Functions in Indian Young Adults: A Cross-Sectional Study.Indian journal of psychological medicine · 2025Article
- Trend analyses and comparison of characteristics of current-, former- and never-drinkers among young adults in France from 2000 to 2021.BMC public health · 2025Article
- Binge drinking in American Indian Alaskan Native college attending students.Ethnicity & health · 2025Article
- Examining within-person associations between alcohol and cannabis use and hooking up among adolescents and young adults in the United States.Addictive behaviors · 2024Article
- Experiencing violence and other predictors of within-person same-day use of multiple substances in youth: a longitudinal study in emergency settings.The American journal of drug and alcohol abuse · 2024Article
- Investigating the associations between prenatal exposure to substances and intergenerational maltreatment and symptoms of psychopathology for adolescent girls from families with low income.Child abuse & neglect · 2024Article
- Individual Differences in Substance Use Motives, Trauma, and Stress Among College-Based Polysubstance Users.Substance use & misuse · 2024Article
- Within-person associations of escalated electronic nicotine delivery systems use with cigarette, alcohol, marijuana and drug use behaviors among US young adults.Addiction (Abingdon, England) · 2023Article
- Nonpartner Violence Perpetration Among Emerging Adults: Associations With Polysubstance Use and Trait Mindfulness.Psychology of violence · 2023Article
- Patterns and contexts of polysubstance use among young and older adults who are involved in the criminal legal system and use opioids: A mixed methods study.Journal of substance abuse treatment · 2022Article
- An exploration of multivariate symptom clusters of cannabis use disorder in young adults.Addictive behaviors · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPolysubstance use (PSU) is associated with worse prognosis and poorer physical and mental health compared to single substance use. The current study provides information about PSU patterns by examining a diverse range of alcohol/substance use behaviors ranging from low-level experimentation to indicators of severe abuse. In addition, the current study, for the first time, examines how simultaneous co-use of multiple substances cluster with other more commonly studied PSU behaviors.
methodsLatent Class Analysis was used to identify patterns of substance use, in a sample of young-adults (n = 2098), using 25 items from the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA-II) including: items assessing severity of problems with alcohol, cannabis, stimulants, opiates, and sedatives; items assessing # of lifetime uses; items assessing simultaneous co-use of all combinations of substances. Then the association of class membership and age, antisocial and impulsive personality, experience seeking, anxiety, and neuroticism was examined using Multinomial Regression.
resultsFit indices (i.e. AIC, SSABIC, and entropy) and interpretability of classes supported a five-class solution: "Low Problems" (32% of sample), "Alcohol Primary" (11%), "Alcohol and Cannabis" (25%), "Moderate PSU" (23%), and "Severe PSU" (9%). Simultaneous co-use behaviors discriminated between lower and higher severity groups. Externalizing personality constructs robustly predicted membership in the "Moderate" and "Severe" PSU classes compared to the "Alcohol Primary" class.
conclusionsPSU patterns followed an additive pattern of use with lower severity classes using alcohol/cannabis and more severe classes using other illicit substances in addition. Co-use items provided valuable information about PSU severity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.