Evidence map›Paper›PMID 31705907›Full record

ReviewThe Journal of allergy and clinical immunology2020

Emerging therapies for eosinophilic esophagitis.

Thomas Greuter, Ikuo Hirano, Evan S Dellon

Open access · greenAbstract readReview
In one paragraph

Review in The Journal of allergy and clinical immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 2 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 81 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. [Eosinophilic esophagitis].Innere Medizin (Heidelberg, Germany) · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Eosinophilic Esophagitis: What's in a Name?Digestive diseases and sciences · 2024
    Article
  11. Article
  12. Article
  13. Successful use of dupilumab for egg-induced eosinophilic gastroenteritis with duodenal ulcer: a pediatric case report and review of literature.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2023
    Article
  14. Article
  15. Review
  16. Higher Body Mass Index Is Associated With Decreased Treatment Response to Topical Steroids in Eosinophilic Esophagitis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2023
    Article
  17. Pre-treatment differential correlation of gene expression and response to topical steroids in eosinophilic esophagitis.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2023
    Article
  18. Article
  19. Article
  20. EoE behaves as a unique Th2 disease: a narrative review.Translational gastroenterology and hepatology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 3 countries.

Thomas GreuterDepartment of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland.
Ikuo HiranoDivision of Gastroenterology and Hepatology, Northwestern University, Chicago, Ill.
Evan S DellonDivision of Gastroenterology and Hepatology, UNC Hospital, Chapel Hill, NC. Electronic address: edellon@med.unc.edu.
Northwestern University · PHUniversity Hospital of Zurich · CHUniversity of North Carolina Health Care · US

Funding

The Impact of COVID-19 on People Living with Rare Diseases and Their FamiliesU2CTR002818 · NCATS · CINCINNATI CHILDRENS HOSP MED CTR · PI Michal Kouril · 2019 to 2026
$51.2M
TRAINING (CAREER DEVELOPMENT) COMPONENTU54AI117804 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI Nirmala P Gonsalves · 2014 to 2026
$18.5M
NCATS NIH HHS U2C TR002818NIAID NIH HHS U54 AI117804
6 · The paper itself

Abstract

Despite advances in the pathologic understanding of eosinophilic esophagitis (EoE), as of yet, no single agent has been approved by the US Food and Drug Administration to treat EoE. Off-label, EoE is currently treated by using the 3 Ds: drugs (particularly swallowed topical corticosteroids), dietary restriction, and endoscopic dilation. In the recent past, considerable progress in terms of EoE treatment has been made: (1) new EoE-specific steroid formulations optimizing mucosal deposition have been developed, which has culminated in recent approval of a budesonide effervescent tablet in Europe; (2) biologics used for other T

Indexed as

Diet TherapyOff-Label UseAdrenal Cortex HormonesBudesonideClinical Trials, Phase II as TopicEosinophilic EsophagitisHumansAdrenal Cortex HormonesBudesonidebiologicsdietEosinophilic esophagitissteroidstreatment

Identifiers

PMID31705907
PMCPMC6981295
OpenAlexW2989157621

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.