Evidence map›Paper›PMID 31705897›Full record

ArticleExperimental eye research2020

Spatiotemporal distribution of chondroitin sulfate proteoglycans after optic nerve injury in rodents.

Craig S Pearson, Andrea G Solano, Sharada M Tilve, Caitlin P Mencio, Keith R Martin, Herbert M Geller

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental eye research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Role of Chondroitin Sulfation Following Spinal Cord Injury.Frontiers in cellular neuroscience · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Craig S PearsonLaboratory of Developmental Neurobiology, National Heart, Lung, Blood Institute, National Institutes of Health, Bethesda, MD, USA; Department of Clinical Neurosciences, University of Cambridge, United Kingdom.
Andrea G SolanoLaboratory of Developmental Neurobiology, National Heart, Lung, Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Sharada M TilveLaboratory of Developmental Neurobiology, National Heart, Lung, Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Caitlin P MencioLaboratory of Developmental Neurobiology, National Heart, Lung, Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Keith R MartinDepartment of Clinical Neurosciences, University of Cambridge, United Kingdom.
Herbert M GellerLaboratory of Developmental Neurobiology, National Heart, Lung, Blood Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: gellerh@nhlbi.nih.gov.
National Heart Lung and Blood Institute · USUniversity of Cambridge · GB

Funding

NATIONAL RESEARCH SERVICE AWARD-MEDICAL SCIENTISTT32GM007200 · NIGMS · WASHINGTON UNIVERSITY · PI YOKOYAMA, WAYNE M. · 1985 to 2024
$59.8M
Signaling by Chondroitin Sulfate ProteoglycansZIAHL006021 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI GELLER, HERBERT M. · 2009 to 2022
$12.3M
Translational Studied of Chondroitin Sulfate ProteoglycansZIAHL006135 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI GELLER, HERBERT M. · 2011 to 2022
$2.3M
Intramural NIH HHS ZIA HL006135NIGMS NIH HHS T32 GM007200
6 · The paper itself

Abstract

The accumulation of chondroitin sulfate proteoglycans (CSPGs) in the glial scar following acute damage to the central nervous system (CNS) limits the regeneration of injured axons. Given the rich diversity of CSPG core proteins and patterns of GAG sulfation, identifying the composition of these CSPGs is essential for understanding their roles in injury and repair. Differential expression of core proteins and sulfation patterns have been characterized in the brain and spinal cord of mice and rats, but a comprehensive study of these changes following optic nerve injury has not yet been performed. Here, we show that the composition of CSPGs in the optic nerve and retina following optic nerve crush (ONC) in mice and rats exhibits an increase in aggrecan, brevican, phosphacan, neurocan and versican, similar to changes following spinal cord injury. We also observe an increase in inhibitory 4-sulfated (4S) GAG chains, which suggests that the persistence of CSPGs in the glial scar opposes the growth of CNS axons, thereby contributing to the failure of regeneration and recovery of function.

Indexed as

AggrecansAnimalsBrevicanChondroitin Sulfate ProteoglycansCrush InjuriesDisease Models, AnimalDrug CombinationsFemaleGlycosaminoglycansImmunohistochemistryMiceMice, Inbred C57BLNeurocanOptic NerveOptic Nerve InjuriesRatsAggrecansBrevicanChondroitin Sulfate ProteoglycansDrug CombinationsGlycosaminoglycansNeurocanReceptor-Like Protein Tyrosine Phosphatases, Class 5SulfamonomethoxinesulfatonTrimethoprimVersicansExtracellular matrixGlycosaminoglycan sulfationImmunocytochemistryOptic nerve crush

Identifiers

PMID31705897
PMCPMC7096184
OpenAlexW2985667566

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.