Evidence map›Paper›PMID 31705730›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2020

Split liver transplantation is utilized infrequently and concentrated at few transplant centers in the United States.

Jin Ge, Emily R Perito, John Bucuvalas, Richard Gilroy, Evelyn K Hsu, John P Roberts, Jennifer C Lai

Open access · greenAbstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
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  8. Liver simulated allocation model does not effectively predict organ offer decisions for pediatric liver transplant candidates.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021
    Article
  9. Article
  10. Article
  11. A Novel Strategy for Preventing Posttransplant Large-For-Size Syndrome in Adult Liver Transplant Recipients: A Pilot Study.Transplant international : official journal of the European Society for Organ Transplantation
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Jin GeDivision of Gastroenterology and Hepatology, Department of Medicine, University of California - San Francisco, San Francisco, California, USA.ORCID 0000-0003-1574-1525
Emily R PeritoDivision of Gastroenterology and Hepatology, Department of Pediatrics, University of California - San Francisco, San Francisco, California, USA.
John BucuvalasMount Sinai Kravis Children's Hospital and Recanati/Miller Transplant Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Richard GilroyLiver Transplant Program, Intermountain Medical Center, Murray, Utah, USA.
Evelyn K HsuDivision of Gastroenterology and Hepatology, Seattle Children's Hospital, Seattle, Washington, USA.
John P RobertsDivision of Transplant Surgery, Department of Surgery, University of California - San Francisco, San Francisco, California, USA.
Jennifer C LaiDivision of Gastroenterology and Hepatology, Department of Medicine, University of California - San Francisco, San Francisco, California, USA.ORCID 0000-0003-2092-6380
University of California, San Francisco · USIcahn School of Medicine at Mount Sinai · USIntermountain Medical Center · USSeattle Children's Hospital · US

Funding

The spectrum of cognitive impairment including Alzheimer’s Disease and Related Dementias after liver transplantationR01AG059183 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jennifer C. Lai · 2018 to 2026
$9.9M
NRSA Hepatology Training GrantT32DK060414 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Mandana Khalili, JACQUELYN J. MAHER · 2002 to 2026
$6.8M
Frailty and Functional Status in Older Liver Transplant PatientsK23AG048337 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LAI, JENNIFER C. · 2014 to 2018
$911k
NIA NIH HHS K23 AG048337NIA NIH HHS R01 AG059183NIDDK NIH HHS T32 DK060414
6 · The paper itself

Abstract

Split liver transplantation (SLT) is 1 strategy for maximizing the number of deceased donor liver transplants. Recent reports suggest that utilization of SLT in the United States remains low. We examined deceased donor offers that were ultimately split between 2010 and 2014. SLTs were categorized as "primary" and "secondary" transplants. We analyzed allocation patterns and used logistic regression to evaluate factors associated with secondary split discard. Four hundred eighteen livers were split: 54% from adult, 46% from pediatric donors. Of the 227 adult donor livers split, 61% met United Network for Organ Sharing "optimal" split criteria. A total of 770 recipients (418 primary and 352 secondary) were transplanted, indicating 16% discard. Ninety-two percent of the 418 primary recipients were children, and 47% were accepted on the first offer. Eighty-seven percent of the 352 secondary recipients were adults, and 7% were accepted on the first offer. Of the 352 pairs, 99% were transplanted in the same region, 36% at the same center. In logistic regression, shorter donor height was associated with secondary discard (odds ratio 0.97 per cm, 95% CI 0.94-1.00, P = .02). SLT volume by center was not predictive of secondary discard. Current policy proposals that incentivize SLT in the United States could increase the number of transplants to children and adults.

Indexed as

Liver TransplantationTissue and Organ ProcurementTransplantsAdultChildGraft SurvivalHumansLiving DonorsTissue DonorsUnited Statesdisparitiesdonors and donationethics and public policyhealth services and outcomes researchliver transplantation/hepatologyliver transplant: splitorgan allocationorgan procurement and allocationOrgan Procurement and Transplantation Network (OPTN)pediatrics

Identifiers

PMID31705730
PMCPMC7103556
OpenAlexW2984824389

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.