Evidence map›Paper›PMID 31705723›Full record

ArticleThe European journal of neuroscience2020

Number of subjects required in common study designs for functional GABA magnetic resonance spectroscopy in the human brain at 3 Tesla.

Faezeh Sanaei Nezhad, Caroline A Lea-Carnall, Adriana Anton, JeYoung Jung, Emilia Michou, Stephen R Williams, Laura M Parkes

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The European journal of neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Faezeh Sanaei NezhadDivision of Informatics, Imaging and Data Science, University of Manchester, Manchester, UK.ORCID 0000-0002-8698-9467
Caroline A Lea-CarnallDivision of Neuroscience and Experimental Psychology, University of Manchester, Manchester, UK.ORCID 0000-0001-6814-3356
Adriana AntonDivision of Neuroscience and Experimental Psychology, University of Manchester, Manchester, UK.ORCID 0000-0002-1356-4513
JeYoung JungSchool of Psychology, University of Nottingham, Nottingham, UK.
Emilia MichouSchool of Rehabilitation Sciences, University of Patras, Patras, Greece.
Stephen R WilliamsDivision of Informatics, Imaging and Data Science, University of Manchester, Manchester, UK.
Laura M ParkesDivision of Neuroscience and Experimental Psychology, University of Manchester, Manchester, UK.
University of Manchester · GBUniversity of Nottingham · GBUniversity of Patras · GR

Funding

TR&D 4: Algorithms for functional and anatomical brain analysisP41EB015909 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VAN ZIJL, PETER CM · 2012 to 2020
$13.1M
Universal GABA-edited MRS at 3TR01EB016089 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI Richard Anthony Edward Edden · 2013 to 2026
$5.4M
Simultaneous Hadamard Editing of GABA and GlutathioneR01EB023963 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI EDDEN, RICHARD ANTHONY EDWARD · 2017 to 2024
$3.8M
Medical Research Council MR/J004146/1Medical Research Council MR/K020803/1Medical Research Council MR/P014445/1NIBIB NIH HHS P41 EB015909NIBIB NIH HHS R01 EB016089NIBIB NIH HHS R01 EB023963
6 · The paper itself

Abstract

Magnetic resonance spectroscopy (MRS) is a research tool for measuring the concentration of metabolites such as γ-aminobutyric acid (GABA) and glutamate in the brain. MEGA-PRESS has been the preferred pulse sequence for GABA measurements due to low physiological GABA concentrations, hence low signal. To compensate, researchers incorporate long acquisition durations (7-10 min) making functional measurements of this metabolite challenging. Here, the acquisition duration and sample sizes required to detect specific concentration changes in GABA using MEGA-PRESS at 3 T are presented for both between-groups and within-session study designs. 75 spectra were acquired during rest using MEGA-PRESS from 41 healthy volunteers in 6 different brain regions at 3 T with voxel sizes between 13 and 22 cm

Indexed as

gamma-Aminobutyric AcidMagnetic Resonance ImagingBrainGlutamic AcidHumansMagnetic Resonance Spectroscopygamma-Aminobutyric AcidGlutamic AcidfMRSGABAMEGA-PRESSpower calculationprecisionquantification

Identifiers

PMID31705723
PMCPMC7216844
OpenAlexW2986796043

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.