Evidence map›Paper›PMID 31705491›Full record

ArticleAdvances in experimental medicine and biology2019

Neuroimaging of Small Vessel Disease in Late-Life Depression.

Nadim S Farhat, Robert Theiss, Tales Santini, Tamer S Ibrahim, Howard J Aizenstein

Abstract read
In one paragraph

Article in Advances in experimental medicine and biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Nadim S FarhatDepartment of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA.
Robert TheissSchool of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Tales SantiniDepartment of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA.
Tamer S IbrahimDepartment of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA. tibrahim@pitt.edu.
Howard J AizensteinDepartment of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA. aizen@pitt.edu.
University of Pittsburgh · US

Funding

Imaging Advancements in Small Vessel and CSF Flow Pathophysiology of Pre-clinical Alzheimer's DiseaseR01AG063525 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AIZENSTEIN, HOWARD J, COHEN, ANN D. · 2019 to 2023
$3.7M
High Performance Imaging for Assessment of Small Vessel Disease in Older Adults with DepressionR01MH111265 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AIZENSTEIN, HOWARD J, IBRAHIM, TAMER S · 2016 to 2020
$3.6M
NIA NIH HHS R01 AG063525NIMH NIH HHS R01 MH111265
6 · The paper itself

Abstract

Cerebral small vessel disease is associated with late-life depression, cognitive impairment, executive dysfunction, distress, and loss of life for older adults. Late-life depression is becoming a substantial public health burden, and a considerable number of older adults presenting to primary care have significant clinical depression. Even though white matter hyperintensities are linked with small vessel disease, white matter hyperintensities are nonspecific to small vessel disease and can co-occur with other brain diseases. Advanced neuroimaging techniques at the ultrahigh field magnetic resonance imaging are enabling improved characterization, identification of cerebral small vessel disease and are elucidating some of the mechanisms that associate small vessel disease with late-life depression.

Indexed as

AgingAgedBrainCerebral Small Vessel DiseasesDepressionHumansMagnetic Resonance ImagingNeuroimagingWhite MatterCerebral microvascular mechanismsCerebral small vessel diseaseLate-life depressionMagnetic resonance imagingTic-tac-toe radiofrequency head coilUltrahigh field

Identifiers

PMID31705491
PMCPMC6939470
OpenAlexW2983358776

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.