Evidence map›Paper›PMID 31705484›Full record

ReviewCurrent nutrition reports2019

Ketogenic Diet: an Endocrinologist Perspective.

Aravind Reddy Kuchkuntla, Meera Shah, Saketh Velapati, Victoria M Gershuni, Tamim Rajjo, Sanjeev Nanda, Ryan T Hurt, Manpreet S Mundi

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current nutrition reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Expression and significance of ependymin-related protein 1 and neuregulin 4 in the serum of patients with polycystic ovary syndrome.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Ketone bodies as chemical signals for the immune system.American journal of physiology. Cell physiology · 2024
    Article
  11. Article
  12. Brain Injury: How Dietary Patterns Impact Long-Term Outcomes.Current physical medicine and rehabilitation reports · 2023
    Review
  13. Article
  14. Article
  15. The effect of ketogenic diet on thyroid functions in children with drug-resistant epilepsy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Article
  16. Article
  17. Review
  18. Observational
  19. The Ketogenic Diet Revisited: Beyond Ketones.Frontiers in neurology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Aravind Reddy KuchkuntlaDepartment of Family Medicine, Mayo Clinic, Rochester, MN, USA.
Meera ShahDivision of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, 200 1st Street SW, Rochester, MN, 55905, USA.
Saketh VelapatiDivision of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, 200 1st Street SW, Rochester, MN, 55905, USA.
Victoria M GershuniDepartment of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Tamim RajjoDepartment of Family Medicine, Mayo Clinic, Rochester, MN, USA.
Sanjeev NandaDivision of General Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Ryan T HurtDivision of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, 200 1st Street SW, Rochester, MN, 55905, USA.
Manpreet S MundiDivision of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, 200 1st Street SW, Rochester, MN, 55905, USA. Mundi.manpreet@mayo.edu.
Mayo Clinic · USMayo Clinic in Arizona · USWinnMed · USHospital of the University of Pennsylvania · US

Funding

NRSA Training CoreTL1TR001880 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI MEAGHER, EMMA ANNE · 2016 to 2025
$10.0M
6 · The paper itself

Abstract

purpose of reviewObesity and its related comorbidities make up a large part of healthcare expenditures. Despite a wide array of options for treatment of obesity, rates of sustained weight loss continue to be low, leading patients to seek alternative treatment options. Although the first medically utilized ketogenic diet was described nearly 100 years ago, it has made a resurgence as a treatment option for obesity. Despite increased popularity in the lay public and increased use of ketogenic dietary strategies for metabolic therapy, we are still beginning to unravel the metabolic impact of long-term dietary ketosis. RECENT

findingsThere are a number of recent trials that have highlighted the short- and long-term benefits of ketogenic diet on weight, glycemic control, and other endocrine functions including reproductive hormones. This review is a summary of available data on the effectiveness and durability of the ketogenic diet when compared to conventional interventions. Ketogenic dietary strategies may play a role in short-term improvement of important metabolic parameters with potential for long-term benefit. However, response may vary due to inter-individual ability to maintain long-term carbohydrate restriction.

Indexed as

Diet, KetogenicDiet, ReducingEndocrinologistsBlood GlucoseBody WeightDiabetes Mellitus, Type 2Dietary CarbohydratesGlycemic IndexHumansInsulinKetone BodiesKetosisObesityTestosteroneThyroid HormonesWeight LossBlood GlucoseDietary CarbohydratesInsulinKetone BodiesTestosteroneThyroid HormonesDiabetesKetogenic dietObesityWeight loss

Identifiers

PMID31705484
OpenAlexW2988466397

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.