ArticleMolecular neurobiology2020
The Homeodomain Transcription Factors Vax1 and Six6 Are Required for SCN Development and Function.
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Article in Molecular neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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15citing papers in PubMed, 1 pooled it
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- New Insights on the Regulatory Gene Network Disturbed in Central Areolar Choroidal Dystrophy-Beyond Classical Gene Candidates.Frontiers in genetics · 2022Pooled it
- The Transcription Factors Six3 and Six6 in Neuromedin-S Neurons Differentially Affect Circadian Rhythms.Journal of neuroscience research · 2026Article
- Time-of-Day Impacts Uterine Circadian Rhythms and Response to Oxytocin: Comparison of Uterine Function in Melatonin-Deficient C57BL/6 Versus Melatonin Proficient CBA/B6 Hybrid Mice.Journal of pineal research · 2026Article
- Integrated multi-sample transcriptomic analysis of COVID-19 patients against controls using a bioinformatics pipeline.Scientific reports · 2025Article
- Interorgan rhythmicity as a feature of healthful metabolism.Cell metabolism · 2024Review
- The Suprachiasmatic Nucleus at 50: Looking Back, Then Looking Forward.Journal of biological rhythms · 2024Review
- Neuronal reprogramming of mouse and human fibroblasts using transcription factors involved in suprachiasmatic nucleus development.iScience · 2024Article
- The transcription factor VAX1 in VIP neurons of the suprachiasmatic nucleus impacts circadian rhythm generation, depressive-like behavior, and the reproductive axis in a sex-specific manner in mice.Frontiers in endocrinology · 2023Article
- Circadian Rhythms in the Neuronal Network Timing the Luteinizing Hormone Surge.Endocrinology · 2022Review
- SOX2 Regulates Neuronal Differentiation of the Suprachiasmatic Nucleus.International journal of molecular sciences · 2021Article
- Whole-genome resequencing of three Coilia nasus population reveals genetic variations in genes related to immune, vision, migration, and osmoregulation.BMC genomics · 2021Article
- The transcription factors SIX3 and VAX1 are required for suprachiasmatic nucleus circadian output and fertility in female mice.Journal of neuroscience research · 2021Article
- Kiss1 is differentially regulated in male and female mice by the homeodomain transcription factor VAX1.Molecular and cellular endocrinology · 2021Article
- Transcription Factor VAX1 Regulates the Regional Specification of the Subpallium Through Repressing Gsx2.Molecular neurobiology · 2021Article
- Role of core circadian clock genes in hormone release and target tissue sensitivity in the reproductive axis.Molecular and cellular endocrinology · 2020Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Erica C PandolfiDepartment of Obstetrics, Gynecology, and Reproductive Sciences and Center for Reproductive Science and Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.ORCID http://orcid.org/0000-0002-3355-5964
Joseph A BreuerDepartment of Obstetrics, Gynecology, and Reproductive Sciences and Center for Reproductive Science and Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
Viet Anh Nguyen HuuViterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA, 92093, USA.
Tulasi TalluriReproductive and Developmental Science Group, Department of Animal Science, Michigan State University, 474 S Shaw Lane, East Lansing, MI, 48824, USA.
Duong NguyenReproductive and Developmental Science Group, Department of Animal Science, Michigan State University, 474 S Shaw Lane, East Lansing, MI, 48824, USA.
Jessica Sora LeeDepartment of Obstetrics, Gynecology, and Reproductive Sciences and Center for Reproductive Science and Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
Rachael HuDepartment of Obstetrics, Gynecology, and Reproductive Sciences and Center for Reproductive Science and Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
Kapil BhartiUnit on Ocular and Stem Cell Translational Research, National Eye Institute, NIH, Bethesda, MD, 20892, USA.
Dorota Skowronska-KrawczykViterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA, 92093, USA.ORCID http://orcid.org/0000-0002-5758-4225
Michael R GormanCenter for Circadian Biology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.ORCID http://orcid.org/0000-0001-6122-8437
Pamela L MellonDepartment of Obstetrics, Gynecology, and Reproductive Sciences and Center for Reproductive Science and Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.ORCID http://orcid.org/0000-0002-8856-0410
Hanne M HoffmannDepartment of Obstetrics, Gynecology, and Reproductive Sciences and Center for Reproductive Science and Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA. hanne@msu.edu.ORCID http://orcid.org/0000-0003-1555-1369
University of California San Diego · USMichigan State University · USNational Eye Institute · US
Funding
VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jesse Nodora · 1985 to 2026
$124.9MYeast Genetics and Stress Response Genes-BiomedicalP42ES010337 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TUKEY, ROBERT H · 2000 to 2022
$69.8MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4MVision BiostatisticsP30EY022589 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LINDA M ZANGWILL · 2012 to 2026
$10.3MMentoring Young Minds to Increase Diversity in the Biomedical ResearchR25GM083275 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DE MAIO, ANTONIO, LAWSON, MARK ANDREW · 2008 to 2022
$9.9MTestosterone-GnRH Frequency and the Evolution of PCOS in AdolescenceP50HD028934 · NICHD · UNIVERSITY OF VIRGINIA · PI HAISENLEDER, DANIEL J. · 2014 to 2018
$8.6MThe Role of FSH in Female InfertilityP50HD012303 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LAWSON, MARK ANDREW · 1985 to 2020
$7.5MNeurosecretory Gene Expression in the HypothalamusR01HD100580 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MELLON, PAMELA L · 2020 to 2024
$2.7MThe Role of Cognitive Skills and Language Experience in Grammatical ProcessingR01HD098652 · NICHD · VANDERBILT UNIVERSITY · PI WATSON, DUANE G · 2020 to 2024
$2.6MTransfer: Molecular Mechanisms of GlaucomaR01EY027011 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SKOWRONSKA-KRAWCZYK, DOROTA · 2017 to 2022
$2.3MCRR LIGAND ASSAY AND ANALYSIS CORER24HD102061 · NICHD · UNIVERSITY OF VIRGINIA · PI HAISENLEDER, DANIEL J. · 2019 to 2023
$2.2MNeurosecretory Gene Expression in the HypothalamusR01HD072754 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MELLON, PAMELA L · 2012 to 2016
$1.7MEunice Kennedy Shriver National Institute of Child Health and Human Development CA023100Eunice Kennedy Shriver National Institute of Child Health and Human Development DK063491Eunice Kennedy Shriver National Institute of Child Health and Human Development ES010337Eunice Kennedy Shriver National Institute of Child Health and Human Development GM083275Eunice Kennedy Shriver National Institute of Child Health and Human Development HD012303Eunice Kennedy Shriver National Institute of Child Health and Human Development HD072754Eunice Kennedy Shriver National Institute of Child Health and Human Development HD082567Eunice Kennedy Shriver National Institute of Child Health and Human Development HD084759Eunice Kennedy Shriver National Institute of Child Health and Human Development HD098652National Institute of Food and Agriculture 1018024NCI NIH HHS P30 CA023100NEI NIH HHS EY027011NEI NIH HHS P30 EY022589NEI NIH HHS R01 EY027011NICHD NIH HHS F31 HD089652NICHD NIH HHS K99 HD084759NICHD NIH HHS P50 HD012303NICHD NIH HHS P50 HD028934NICHD NIH HHS R00 HD084759NICHD NIH HHS R01 HD072754NICHD NIH HHS R01 HD082567NICHD NIH HHS R01 HD098652NICHD NIH HHS R01 HD100580NICHD NIH HHS R24 HD102061NIDDK NIH HHS P30 DK063491NIEHS NIH HHS P42 ES010337NIGMS NIH HHS R25 GM083275NINDS NIH HHS IRP finds
Abstract
The brain's primary circadian pacemaker, the suprachiasmatic nucleus (SCN), is required to translate day-length and circadian rhythms into neuronal, hormonal, and behavioral rhythms. Here, we identify the homeodomain transcription factor ventral anterior homeobox 1 (Vax1) as required for SCN development, vasoactive intestinal peptide expression, and SCN output. Previous work has shown that VAX1 is required for gonadotropin-releasing hormone (GnRH/LHRH) neuron development, a neuronal population controlling reproductive status. Surprisingly, the ectopic expression of a Gnrh-Cre allele (Gnrh
Indexed as
AnimalsCircadian RhythmGene Expression RegulationGonadotropin-Releasing HormoneHomeodomain ProteinsHypothalamusMiceNeuronsNeuropeptidesSuprachiasmatic NucleusTrans-ActivatorsTranscription FactorsGonadotropin-Releasing HormoneHomeodomain ProteinsNeuropeptidesSix6 protein, mouseTrans-ActivatorsTranscription FactorsVax1 protein, mouseCircadian rhythmGonadotropin-releasing hormone neuronMouse model validationSine oculis homeobox protein 6Suprachiasmatic nucleusVentral anterior homeobox 1
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