ArticleJournal of clinical monitoring and computing2020
The Peripheral Perfusion Index tracks systemic haemodynamics during general anaesthesia.
Article in Journal of clinical monitoring and computing, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Association between peripheral perfusion index and postoperative acute kidney injury in major noncardiac surgery patients receiving continuous vasopressors: a post hoc exploratory analysis of the VEGA-1 trial.British journal of anaesthesia · 2024Trial
- Comparison of the perfusion index as an index of noxious stimulation in monitored anesthesia care of propofol/remifentanil and propofol/dexmedetomidine: a prospective, randomized, case-control, observational study.BMC anesthesiology · 2023Trial
- To identify normovolemia in humans: The stroke volume response to passive leg raising vs. head-down tilt.Physiological reports · 2022Trial
- Effects of nitroglycerin versus labetalol on peripheral perfusion during deliberate hypotension for sinus endoscopic surgery: a randomized, controlled, double-blinded trial.BMC anesthesiology · 2020Trial
- Induction-Phase Peripheral Perfusion Dynamics and Rocuronium Neuromuscular Blockade Onset: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Study on the correlation between changes in perfusion index under different body positions and the risk of hypotension after anesthetic induction.BMC anesthesiology · 2026Observational
- Proof of concept of noninvasive detection of norepinephrine induced stroke volume changes using perfusion index in cardiac surgery.Scientific reports · 2026Observational
- Peripheral Perfusion Index for Prediction of Fluid Responsiveness in Spontaneously Breathing Critically Ill Patients: A Prospective Observational Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025Article
- Perfusion Index Predicts the Effectiveness of Supraclavicular Brachial Plexus Block in Children Under General Anesthesia: A Randomized Controlled Trial.Anesthesiology research and practice · 2025Article
- Vasoconstriction with phenylephrine increases cardiac output in preload dependent patients.Journal of clinical monitoring and computing · 2024Article
- The Use of the Perfusion Index to Predict Post-Induction Hypotension in Patients Undergoing General Anesthesia: A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2024Review
- Prediction of preload dependency using phenylephrine-induced peripheral perfusion index during general anaesthesia: a prospective observational study.BMC anesthesiology · 2024Observational
- "The peripheral perfusion index discriminates haemodynamic responses to induction of general anaesthesia".Journal of clinical monitoring and computing · 2023Article
- A Perfusion Index-Based Evaluation and Comparison of Peripheral Perfusion in Sevoflurane and Isoflurane Anaesthesia: A Prospective Randomised Controlled Trial.Turkish journal of anaesthesiology and reanimation · 2023Article
- The Perfusion Index of the Ear as a Predictor of Hypotension Following the Induction of Anesthesia in Patients with Hypertension: A Prospective Observational Study.Journal of clinical medicine · 2022Article
- Effect of intraoperative operating table rotation on lower limb perfusion index in patients in the lithotomy position.Medicine · 2022Observational
- Effect of perioperative magnesium sulfate and labetalol infusion on peripheral perfusion and postoperative pain in nasal surgery: a randomized controlled trial.Patient safety in surgery · 2022Article
- What is new in hemodynamic monitoring and management?Journal of clinical monitoring and computing · 2022Review
- Prediction of Fluid Responsiveness by the Effect of the Lung Recruitment Maneuver on the Perfusion Index in Mechanically Ventilated Patients During Surgery.Frontiers in medicine · 2022Article
- Association of the intraoperative peripheral perfusion index with postoperative morbidity and mortality in acute surgical patients: a retrospective observational multicentre cohort study.British journal of anaesthesia · 2021Observational
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stable intraoperative haemodynamics are associated with improved outcome and even short periods of instability are associated with an increased risk of complications. During anaesthesia intermittent non-invasive blood pressure and heart rate remains the cornerstone of haemodynamic monitoring. Continuous monitoring of systemic blood pressure or even -flow requires invasive or advanced modalities creating a barrier for obtaining important real-time haemodynamic insight. The Peripheral Perfusion Index (PPI) is obtained continuously and non-invasively by standard photoplethysmography. We hypothesized that changes in indices of systemic blood flow during general anaesthesia would be reflected in the PPI. PPI, stroke volume (SV), cardiac output (CO) and mean arterial pressure (MAP) were evaluated in 20 patients. During general anaesthesia but before start of surgery relative changes of SV, CO and MAP were compared to the relative changes of PPI induced by head-up (HUT) and head-down tilt (HDT). Furthermore, the effect of phenylephrine (PE) during HUT on these parameters was investigated. ∆PPI correlated significantly (p < 0.001) with ∆SV (r = 0.9), ∆CO (r = 0.9), and ∆MAP (r = 0.9). HUT following induction of anaesthesia resulted in a decrease in PPI of 41% (25-52) [median (IQR)], SV 27% (23-31), CO 27% (25-35), and MAP 28% (22-35). HDT led to an increase in PPI of 203% (120-375), SV of 29% (21-41), CO 22% (16-34), and MAP 47% (42-60). After stabilizing a second HUT decreased PPI 59% (49-76), SV 33% (28-37), CO 31% (28-36), and MAP 34% (26-38). Restoration of preload with PE increased PPI by 607% (218-1078), SV by 96% (82-116), CO by 65% (56-99), and MAP by 114% (83-147). During general anaesthesia changes in PPI tracked changes in systemic haemodynamics.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.