ArticleInternational journal of computer assisted radiology and surgery2020
Interactive exploration of a 3D intracranial aneurysm wall model extracted from histologic slices.
Article in International journal of computer assisted radiology and surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Vasa vasorum plexus formation in intracranial aneurysm associates with microcalcification and wall thickening.Science advances · 2025Article
- Multimodal exploration of the intracranial aneurysm wall.International journal of computer assisted radiology and surgery · 2023Article
- Towards Realistic 3D Models of Tumor Vascular Networks.Cancers · 2023Article
- Shedding the Light on the Natural History of Intracranial Aneurysms: An Updated Overview.Medicina (Kaunas, Lithuania) · 2021Review
- Complex wall modeling for hemodynamic simulations of intracranial aneurysms based on histologic images.International journal of computer assisted radiology and surgery · 2021Article
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Authors and funding
7 authors.
Funding
Abstract
purposeCurrently no detailed in vivo imaging of the intracranial vessel wall exists. Ex vivo histologic images can provide information about the intracranial aneurysm (IA) wall composition that is useful for the understanding of IA development and rupture risk. For a 3D analysis, the 2D histologic slices must be incorporated in a 3D model which can be used for a spatial evaluation of the IA's morphology, including analysis of the IA neck.
methodsIn 2D images of histologic slices, different wall layers were manually segmented and a 3D model was generated. The nuclei were automatically detected and classified as round or elongated, and a neural network-based wall type classification was performed. The information was combined in a software prototype visualization providing a unique view of the wall characteristics of an IA and allowing interactive exploration. Furthermore, the heterogeneity (as variance of the wall thickness) of the wall was evaluated.
resultA 3D model correctly representing the histologic data was reconstructed. The visualization integrating wall information was perceived as useful by a medical expert. The classification produces a plausible result.
conclusionThe usage of histologic images allows to create a 3D model with new information about the aneurysm wall. The model provides information about the wall thickness, its heterogeneity and, when performed on cadaveric samples, includes information about the transition between IA neck and sac.
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