ArticleProtein & cell2020
EGFR signaling augments TLR4 cell surface expression and function in macrophages via regulation of Rab5a activation.
Erratum issuedAbstract readLetter
In one paragraph
Article in Protein & cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- TLR4-paxillin-Rac1 signaling mediates LPS-induced dysregulation of keratinocyte function.iScience · 2026Article
- Targeted delivery of doxorubicin using RSV F-protein modified breast cancer-derived exosomes in breast cancer-bearing mice.BioImpacts : BI · 2026Article
- Epidermal growth factor receptor signaling modulates postoperative pain and inflammatory responses.Frontiers in immunology · 2026Review
- EGFR: New Insights on Its Activation and Mutation in Tumor and Tumor Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Unraveling the Role of Metabolic Endotoxemia in Accelerating Breast Tumor Progression.Biomedicines · 2025Article
- LPS-induced extracellular AREG triggers macrophage pyroptosis through the EGFR/TLR4 signaling pathway.Frontiers in immunology · 2025Article
- Osimertinib exacerbates immune checkpoint inhibitor-related severe adverse events by activating the IL-6/JAK/STAT3 pathway in macrophages.Cancer biology & medicine · 2024Article
- EGFR of platelet regulates macrophage activation and bacterial phagocytosis function.Journal of inflammation (London, England) · 2024Article
- Tissue-resident macrophages exacerbate lung injury after remote sterile damage.Cellular & molecular immunology · 2024Article
- Propofol improves survival in a murine model of sepsis via inhibiting Rab5a-mediated intracellular trafficking of TLR4.Journal of translational medicine · 2024Article
- Myeloid differentiation factor 2 inhibitors exert protective effects on lipopolysaccharides-treated human dental pulp cells via suppression of toll-like receptor 4-mediated signaling.Journal of dental sciences · 2024Article
- EGFR promotes the apoptosis of CD4Journal of advanced research · 2023Article
- Qishen Granule (QSG) Inhibits Monocytes Released From the Spleen and Protect Myocardial Function via the TLR4-MyD88-NF-κB p65 Pathway in Heart Failure Mice.Frontiers in pharmacology · 2022Article
- Erlotinib protests against LPS-induced parthanatos through inhibiting macrophage surface TLR4 expression.Cell death discovery · 2021Article
- Respiratory syncytial virus activates Rab5a to suppress IRF1-dependent IFN-λ production, subverting the antiviral defense of airway epithelial cells.Journal of virology · 2021Article
- Remimazolam Protects Against LPS-Induced Endotoxicity Improving Survival of Endotoxemia Mice.Frontiers in pharmacology · 2021Article
- Modulation of Pathological Pain by Epidermal Growth Factor Receptor.Frontiers in pharmacology · 2021Review
- Inhibition of TLR4 Signaling Impedes Tumor Growth in Colitis-Associated Colon Cancer.Frontiers in immunology · 2021Article
- Functionally distinct resident macrophage subsets differentially shape responses to infection in the bladder.Science advances · 2020Article
Corrections and comments
- Erratum issued
- Erratum issued
Authors and funding
12 authors.
Jing TangThe Department of Anesthesiology, Affiliated hospital of Guangdong Medical University, Zhanjiang, 524000, China. tanglitangjing@126.com.ORCID http://orcid.org/0000-0003-1646-3504
Bowei ZhouDepartment of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Melanie J ScottDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.
Linsong ChenDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.
Dengming LaiDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.
Erica K FanUniversity of Pittsburgh The Graduate School of Public Health, Pittsburgh, PA, 15213, USA.
Yuehua LiDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.
Qiang WuLaboratory of Tropical Biomedicine and Biotechnology, School of Tropical Medicine and Laboratory Medicine, Hainan Medical University, Haikou, 571199, China.
Timothy R BilliarDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.
Mark A WilsonDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.
Ping WangThe Feinstein Institute for Medical Research, Manhasset, NY, 11030, USA.
Jie FanDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA. jif7@pitt.edu.ORCID http://orcid.org/0000-0002-0090-2704
Funding
IMPROVEMENT OF ORGAN FUNCTION AFTER SEVERE HYPOVOLEMIAR01HL076179 · NHLBI · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI PING WANG · 2004 to 2026
$7.6MInflammasome activation in trauma-hemorrhagic shockR01GM102146 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SCOTT, MELANIE J. · 2013 to 2025
$4.3MCell Priming, Receptor Cross-Talk, and Acute Lung InjuryR01HL079669 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FAN, JIE, WILSON, MARK A. · 2005 to 2019
$4.0MMacrophage Pyroptosis Mechanism of Post-Trauma Acute Lung InjuryR01HL139547 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FAN, JIE · 2018 to 2021
$1.6MCell Death Mechanism of Acute Lung Injury in SepsisI01BX002729 · VA · VETERANS HEALTH ADMINISTRATION · PI FAN, JIE · 2015 to 2020
–BLR&D Research Career Scientist Award ApplicationIK6BX004211 · VA · VETERANS HEALTH ADMINISTRATION · PI FAN, JIE · 2018 to 2022
–BLRD VA I01 BX002729BLRD VA IK6 BX004211NHLBI NIH HHS R01 HL076179NHLBI NIH HHS R01 HL079669NHLBI NIH HHS R01 HL139547NIGMS NIH HHS R01 GM102146
Abstract
PubMed holds no abstract for this paper.
Indexed as
DipeptidesErbB ReceptorsHEK293 CellsHumansHydroxamic AcidsLipopolysaccharidesMacrophagesPhosphorylationQuinazolinesrab5 GTP-Binding ProteinsSignal TransductionSurface PropertiesToll-Like Receptor 4DipeptidesEGFR protein, humanErbB ReceptorsHydroxamic AcidsLipopolysaccharidesN-((2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl)-3-(2'-naphthyl)alanylalanine, 2-aminoethylamidePD168393QuinazolinesRAB5C protein, humanrab5 GTP-Binding ProteinsTLR4 protein, humanToll-Like Receptor 4
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.