Evidence map›Paper›PMID 31705372›Full record

ReviewCurrent treatment options in gastroenterology2019

Hereditary Polyposis Syndromes.

Trilokesh D Kidambi, Divyanshoo R Kohli, N Jewel Samadder, Aparajita Singh

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current treatment options in gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
  2. Genetic predisposition to polyposis syndromes.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Review
  3. Optimizing genetic testing strategy for suspected attenuated adenomatous polyposis: effective solutions in public health systems.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Article
  4. Polyposis found on index colonoscopy in a 56-year-old female -World journal of gastrointestinal endoscopy · 2023
    Article
  5. [Clinical and histopathological characteristics of malignant colon tumors by location].Revista medica del Instituto Mexicano del Seguro Social · 2023
    Observational
  6. Review
  7. Review
  8. Article
  9. Review
  10. Small Bowel Epithelial Precursor Lesions: A Focus on Molecular Alterations.International journal of molecular sciences · 2021
    Review
  11. Review
  12. Article
  13. Article
  14. Gut Microbial Signatures in Sporadic and Hereditary Colorectal Cancer.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Trilokesh D KidambiDivision of Gastroenterology, City of Hope National Medical Center, Duarte, CA, USA.
Divyanshoo R KohliDivision of Gastroenterology, Kansas City Veterans Affair Medical Center, Kansas City, MO, USA.
N Jewel SamadderDivision of Gastroenterology and Hepatology, Department of Clinical Genomics, Mayo Clinic, Phoenix, AZ, USA.
Aparajita SinghDivision of Gastroenterology, University of California San Francisco, 505 Parnassus Ave, Room S357, San Francisco, CA, 941943, USA. Aparajita.Singh@ucsf.edu.
City Of Hope National Medical Center · USKansas City VA Medical Center · USMayo Clinic in Florida · USUniversity of California, San Francisco · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewColorectal cancer (CRC) is the third most common cancer in the USA and inherited cancer syndromes are responsible for approximately 3-5% of all CRCs. Genetic testing costs have plummeted in recent years; however, awareness and referral of high-risk patients for testing is still very low. We review the salient clinical features, genetics, and management of well-defined gastrointestinal (GI) hereditary polyposis syndromes including familial adenomatous polyposis, MUTYH-associated polyposis, and the hamartomatous polyposis syndromes. RECENT

findingsComprehensive endoscopic surveillance has the potential to prevent the development of GI cancer and to identify early-stage cancer; newer developments like high-definition endoscopes, chromoendoscopy, and the use of cap-assisted endoscopy have shown promise for enhanced lesion detection rates. Several chemoprevention trials have yielded promising results but safety and efficacy data for long-term use is still awaited. Several new polyposis genes have also been identified in the recent years. Multiple societies have recently published updated surveillance guidelines to aid clinicians in the detection and management of patients with hereditary GI polyposis syndromes. Although these syndromes are rare, it is crucial for the clinicians to recognize these in a timely manner, for the appropriate management plans for both the patient and their at risk family members.

Indexed as

Cowden syndromeFamilial adenomatous polyposisHereditary colon cancerJuvenile polyposisPeutz-Jeghers syndromePolyposis

Identifiers

PMID31705372
OpenAlexW2985983784

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.