ArticleClinical oral investigations2020
In vitro remineralization of enamel white spot lesions with a carrier-based amorphous calcium phosphate delivery system.
Article in Clinical oral investigations, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- Antibacterial Interventions for Orthodontic Appliances; Surface Modifications, Coatings and Bulk-Incorporated Antibacterial Agents: Materials, Mechanisms and Clinical Application-A Scoping Review.Materials (Basel, Switzerland) · 2026Review
- Application of Polymers in Advanced Materials for Enamel and Dentine Remineralization.ACS biomaterials science & engineering · 2026Review
- Article
- Evaluation of Remineralization of White Spot Lesions with Quercetin Nanoparticles: AnJournal of clinical and experimental dentistry · 2025Article
- Effect of different protocols in preventing demineralization in irradiated human enamel, in vitro study.BMC oral health · 2025Article
- Enamel remineralisation prospect of Moringa Oleifera hydrogel, eggshell hydrogel versus sodium fluoride varnish on artificially demineralised primary teeth: in vitro study.Acta odontologica Scandinavica · 2024Article
- In vitro evaluation of an easy-to-remove orthodontic adhesive with photochromic property.The Angle orthodontist · 2024Article
- Amelogenin-inspired peptide, calcium phosphate solution, fluoride and their synergistic effect on enamel biomimetic remineralization: an in vitro pH-cycling model.BMC oral health · 2024Article
- Remineralization effects of enamel binding peptide, WGNYAYK, on enamel subsurface demineralizationHeliyon · 2024Article
- In vitro evaluation of a novel fluoride-coated clear aligner with antibacterial and enamel remineralization abilities.Clinical oral investigations · 2023Article
- Development of a remineralizing calcium phosphate nanoparticle-containing self-etching system for orthodontic bonding.Clinical oral investigations · 2023Article
- Recent advances in antibacterial coatings for orthodontic appliances.Frontiers in bioengineering and biotechnology · 2023Review
- Synergistic remineralization of enamel white spot lesions using mesoporous bioactive glasses loaded with amorphous calcium phosphate.Frontiers in bioengineering and biotechnology · 2023Article
- The Effect of Biomimetic Remineralization of Calcium Phosphate Ion Clusters-Treated Enamel Surfaces on Bracket Shear Bond Strength.International journal of nanomedicine · 2023Article
- Application of Amorphous Calcium Phosphate Agents in the Prevention and Treatment of Enamel Demineralization.Frontiers in bioengineering and biotechnology · 2022Review
- Drug delivery systems for oral disease applications.Journal of applied oral science : revista FOB · 2022Review
- Rehardening and the Protective Effect of Gamma-Polyglutamic Acid/Nano-Hydroxyapatite Paste on Surface-Etched Enamel.Polymers · 2021Article
- Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesTo achieve in vitro remineralization of enamel white spot lesions (WSLs) via a mesoporous delivery system of amorphous calcium phosphate (ACP) precursors. MATERIALS AND
methodsAmine-functionalized expanded pore mesoporous silica (aMSN) was loaded with polyacrylic acid-stabilized amorphous calcium phosphate (PAA-ACP) to develop a carrier-based delivery system (PAA-ACP@aMSN). Thirty-six artificial WSLs samples were created and randomly assigned to three treatments: artificial saliva solution (negative control, n = 12), casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) slurry (n = 12), and PAA-ACP@aMSN slurry (n = 12). Surface microhardness, Raman intensity, and color were measured before/after artificial demineralization and after remineralization treatments to evaluate the remineralization level of each sample. SEM images were taken on the surface and cross-section of samples to observe microstructure changes.
resultsThe surface microhardness recovery ratio (%SMHRR), Raman intensity change ratio (%ICR), and color recovery ratio (%CRR) were not significantly different between CPP-ACP and PAA-ACP@aMSN groups (P > 0.05), but both of them had significantly higher %SMHRR, %ICR, and %CRR values than negative control (P < 0.01). SEM images showed that apparent enamel prism imprints and inter-prism gaps in negative control were masked by mineral deposition in the PAA-ACP@aMSN and CPP-ACP groups.
conclusionsPAA-ACP@aMSN has an ability to remineralize enamel WSLs. CLINICAL RELEVANCE: The carrier-based amorphous calcium phosphate delivery system has great potential to serve as a remineralizing agent for the treatment of WSLs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.