Evidence map›Paper›PMID 31705257›Full record

ArticleEuropean radiology2020

Comparison between ROI-based and volumetric measurements in quantifying heterogeneity of liver stiffness using MR elastography.

Roya Rezvani Habibabadi, Pegah Khoshpouri, Maryam Ghadimi, Mohammadreza Shaghaghi, Sanaz Ameli, Bita Hazhirkarzar, Pallavi Pandey, Mounes Aliyari Ghasabeh, Ankur Pandey, Ihab R Kamel

Abstract read
PubMed Publisher
In one paragraph

Article in European radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Observational
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Roya Rezvani HabibabadiRussell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Room 143, MRI 143, Baltimore, MD, 21287, USA.
Pegah KhoshpouriRussell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Room 143, MRI 143, Baltimore, MD, 21287, USA.
Maryam GhadimiRussell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Room 143, MRI 143, Baltimore, MD, 21287, USA.
Mohammadreza ShaghaghiRussell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Room 143, MRI 143, Baltimore, MD, 21287, USA.
Sanaz AmeliRussell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Room 143, MRI 143, Baltimore, MD, 21287, USA.
Bita HazhirkarzarRussell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Room 143, MRI 143, Baltimore, MD, 21287, USA.
Pallavi PandeyRussell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Room 143, MRI 143, Baltimore, MD, 21287, USA.
Mounes Aliyari GhasabehRussell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Room 143, MRI 143, Baltimore, MD, 21287, USA.
Ankur PandeyRussell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Room 143, MRI 143, Baltimore, MD, 21287, USA.
Ihab R KamelRussell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Room 143, MRI 143, Baltimore, MD, 21287, USA. ikamel@jhmi.edu.
Johns Hopkins University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study was conducted to quantify the heterogeneity of liver stiffness (LS) on MR elastography (MRE) by comparing ROI-based and volumetric measurements.

methodsLS was measured by ROI-based and volumetric segmentation of the liver parenchyma. Mean LS (MLS) was calculated and used to assign stages of fibrosis. Volumetric measurements of stiffness maps were used to determine the percentage of liver volume above/below MLS and presence of LS heterogeneity. Heterogeneous stiffness was defined when the first and second most predominant stages were more than one category apart. MLS values by each method were compared using the Wilcoxon signed-rank test.

resultsWe included 128 patients with suspected liver fibrosis (mean age 54.4 ± 14.8 years). MLS was 2.7 ± 1.0 kPa for ROI measurements and 2.6 ± 0.9 kPa for the volumetric method (p = 0.001). Of 59 patients with normal stage (F0), 31 patients (52.5%) had > 20% of liver volume with abnormal LS (F1-F4). Heterogeneous LS was reported in 18 patients (14%).

conclusionsMLS measurement may not represent the entire spectrum of hepatic fibrosis. Volumetric segmentation may potentially improve the detection of heterogeneous fibrosis and the accuracy of LS measurement. KEY POINTS: • Heterogeneity of hepatic fibrosis may occur in patients with chronic liver disease. • MR elastography is used to assess hepatic fibrosis by measuring liver stiffness. • Measuring liver stiffness by the ROI method and reporting a mean value may fail to detect heterogeneity of hepatic fibrosis. Volumetric assessment of liver stiffness by MR elastography may detect heterogeneity of parenchymal involvement.

Indexed as

AlgorithmsAdolescentAdultAgedAged, 80 and overElasticityElasticity Imaging TechniquesFemaleHumansLiverLiver CirrhosisMagnetic Resonance ImagingMaleMiddle AgedRetrospective StudiesYoung AdultElasticity imaging techniquesElastographyFibrosisLiver cirrhosisMagnetic resonance elastography

Identifiers

PMID31705257
OpenAlexW2987338291

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.