ArticleNature communications2019
WUSCHEL acts as an auxin response rheostat to maintain apical stem cells in Arabidopsis.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers.
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Who cites it
117 citing papers in PubMed, 199 citations in OpenAlex.
- CRISPR/Cas9-Mediated Knockout of LbSP1 and LbSP5G1 Reveals Efficient Customization of Shoot Architecture in Black Goji Berry.Plant biotechnology journal · 2026Article
- Insights into Candidate Pathways Associated with Multi-Pistil Formation in Chinese Chestnut (Biology · 2026Article
- Dexamethasone-inducible LhGR/pOp system: simple and flexible spatiotemporal control of gene expression.Planta · 2026Review
- Phytohormones and Shoot Branching: A Mini-Review of Molecular Regulatory Networks and Mechanisms.Plants (Basel, Switzerland) · 2026Review
- Brassinosteroid signaling regulates shoot apical meristem homeostasis via orchestrating cytokinin and WUSCHEL activity.Science advances · 2026Article
- Identification and fine mapping of a locus controlling multi-main-stem trait in Brassica napus.BMC plant biology · 2026Article
- Review
- WUSCHEL in forest trees: evolutionary organizer, vascular architect, and totipotency switch.Plant molecular biology · 2026Review
- Article
- WUSCHEL Transcription Factor: From Stem Cell Maintenance to Crop Improvement.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Big data approaches to understanding gene regulatory networks in the shoot apical meristem andFrontiers in plant science · 2026Review
- Regulatory layers of robustness of CLAVATA-WUSCHEL feedback system in stem cell homeostasis.Frontiers in plant science · 2026Review
- TheForestry research · 2026Article
- Large-scale single-cell profiling of stem cells identifies redundant regulators of shoot development and yield trait variation.Developmental cell · 2025Article
- Membrane transport of root-borne trans-zeatin riboside maintains the cytokinin homeostasis in shoots.Journal of experimental botany · 2025Article
- "Bud to bloom"-hormonal coordination in floral initiation.Plant biology (Stuttgart, Germany) · 2025Review
- MONOPTEROS isoform MP11ir plays a role during somatic embryogenesis in Arabidopsis thaliana.Plant physiology · 2025Article
- WUSCHEL-dependent chromatin regulation in maize inflorescence development at single-cell resolution.Genome biology · 2025Article
- The Hidden Architects: Nitric Oxide and Redox Dynamics in Plant Stem Cell Homeostasis.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Integration of bulked segregant analysis and transcriptome sequencing reveals an interaction network associated with cluster buds trait in Brassica napus.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
57 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To maintain the balance between long-term stem cell self-renewal and differentiation, dynamic signals need to be translated into spatially precise and temporally stable gene expression states. In the apical plant stem cell system, local accumulation of the small, highly mobile phytohormone auxin triggers differentiation while at the same time, pluripotent stem cells are maintained throughout the entire life-cycle. We find that stem cells are resistant to auxin mediated differentiation, but require low levels of signaling for their maintenance. We demonstrate that the WUSCHEL transcription factor confers this behavior by rheostatically controlling the auxin signaling and response pathway. Finally, we show that WUSCHEL acts via regulation of histone acetylation at target loci, including those with functions in the auxin pathway. Our results reveal an important mechanism that allows cells to differentially translate a potent and highly dynamic developmental signal into stable cell behavior with high spatial precision and temporal robustness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.