ArticleArchives of disease in childhood. Fetal and neonatal edition2020
Early cortical maturation predicts neurodevelopment in very preterm infants.
Article in Archives of disease in childhood. Fetal and neonatal edition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Pooled it
- 3D ultrasound assessment of the central sulcus in very preterm infants: feasibility and reproducibility of opening metrics study.Scientific reports · 2026Article
- Neuroimaging markers of cognition in late childhood associated with moderate to late preterm birth.Pediatric research · 2026Article
- Associations between postnatal cerebral oxygen availability and utilization in very to late preterm infants and neurodevelopmental outcome.Scientific reports · 2026Observational
- The relationship between sonographically assessed volumetric brain development in VLBW preterm infants and neurodevelopmental outcome at 2 years of age-data from the NeoNEVS project.Frontiers in pediatrics · 2026Article
- Impact of fetal inflammatory response on brain MRI abnormalities in extremely preterm infants.Pediatric research · 2025Article
- Ferreting Out the Effects of Neonatal Hypoxia-Ischemia and Sex on Ferret Cortical Gyrification.Life (Basel, Switzerland) · 2025Article
- The Impacts of Enlarged Subarachnoid Space on Brain Growth and Cortex Maturation in Very Preterm Infants.Diagnostics (Basel, Switzerland) · 2025Article
- Functional connectivity of the superior temporal sulcus at term-equivalent age: effects of gestational age and sex.Brain structure & function · 2025Article
- Relationship Between Cerebral Glucose Metabolism and Neurodevelopmental Outcomes in Very-Low-Birth-Weight Infants without Structural Abnormalities.Nuclear medicine and molecular imaging · 2025Article
- Brain MRI before and at term equivalent age predicts motor and cognitive outcomes in very preterm infants.Neuroimage. Reports · 2025Article
- Differential patterns of cortical expansion in fetal and preterm brain development.bioRxiv : the preprint server for biology · 2025Article
- Cortical scaling of the neonatal brain in typical and altered development.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Foetal cortical expansion is associated with neurodevelopmental outcome at 2-years in congenital heart disease: a longitudinal follow-up study.EBioMedicine · 2025Article
- Early medical risks to language development in extremely preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Early life brain network connectivity antecedents of executive function in children born preterm.Communications biology · 2025Article
- Influencing factors and construction of a predictive model for neurodevelopmental outcomes in preterm low birth weight infants.American journal of translational research · 2025Article
- Contrasting neonatal brain morphometry and its impact on neurodevelopmental outcome between preterm birth and congenital heart disease.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- The neonatal gut microbiota: A role in the encephalopathy of prematurity.Cell reports. Medicine · 2024Article
- Neuroimaging Correlates of the NIH-Toolbox-Driven Cognitive Metrics in Children.Journal of integrative neuroscience · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo evaluate the ability of four objectively defined, cortical maturation features-surface area, gyrification index, sulcal depth and curvature-from structural MRI at term-equivalent age (TEA) to independently predict cognitive and language development at 2 years corrected age in very preterm (VPT) infants.
designPopulation-based, prospective cohort study. Structural brain MRI was performed at term, between 40 and 44 weeks postmenstrual age and processed using the developing Human Connectome Project pipeline.
settingMulticentre study comprising four regional level III neonatal intensive care units in the Columbus, Ohio region. PATIENTS: 110 VPT infants (gestational age (GA) ≤ 31 weeks).
main outcome measuresCognitive and language scores at 2 years corrected age on the Bayley Scales of Infant and Toddler Development, Third Edition.
resultsOf the 94 VPT infants with high-quality T2-weighted MRI scans, 75 infants (80%) returned for Bayley-III testing. Cortical surface area was positively correlated with cognitive and language scores in nearly every brain region. Curvature of the inner cortex was negatively correlated with Bayley scores in the frontal, parietal and temporal lobes. In multivariable regression models, adjusting for GA, sex, socioeconomic status, and injury score on MRI, regional measures of surface area and curvature independently explained more than one-third of the variance in cognitive and language scores at 2 years corrected age in our cohort.
conclusionsWe identified increased cortical curvature at TEA as a new prognostic biomarker of adverse neurodevelopment in very premature infants. When combined with cortical surface area, it enhanced prediction of cognitive and language development. Larger studies are needed to externally validate our findings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.