Evidence map›Paper›PMID 31704714›Full record

ArticleDrug metabolism and disposition: the biological fate of chemicals2020

NRF2-Independent Regulation of Intestinal Constitutive Androstane Receptor by the Pro-Oxidants Cadmium and Isothiocyanate in

Miles Paszek, Robert H Tukey

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug metabolism and disposition: the biological fate of chemicals, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Miles PaszekLaboratory of Environmental Toxicology, Departments of Chemistry and Biochemistry (M.P.) and Pharmacology (R.H.T.), University of California, San Diego, La Jolla, California.
Robert H TukeyLaboratory of Environmental Toxicology, Departments of Chemistry and Biochemistry (M.P.) and Pharmacology (R.H.T.), University of California, San Diego, La Jolla, California rtukey@ucsd.edu.
University of California, San Diego · US

Funding

Yeast Genetics and Stress Response Genes-BiomedicalP42ES010337 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TUKEY, ROBERT H · 2000 to 2022
$69.8M
GRADUATE TRAINING IN CELLULAR &MOLECULAR PHARMACOLOGYT32GM007752 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BROWN, JOAN HELLER, HANDEL, TRACY M · 1985 to 2023
$13.5M
Novel regulatory events that control expression of the UGT1A1 geneR01GM126074 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TUKEY, ROBERT H · 2018 to 2021
$1.2M
NIEHS NIH HHS P42 ES010337NIGMS NIH HHS R01 GM126074NIGMS NIH HHS T32 GM007752
6 · The paper itself

Abstract

Environmental toxicants such as heavy metals from contaminated water or soil and isothiocyanates (ITC) from dietary sources act as pro-oxidants by directly generating reactive oxygen species (ROS) or through depleting cellular antioxidants such as glutathione. Toxicants can alter drug metabolism, and it was reported that CYP2B10 and UGT1A1 are induced by phenethyl isothiocyanate (PEITC) through the constitutive androstane receptor (CAR). The possibility that nuclear factor erythroid 2-related factor 2 (NRF2), the master regulator of the antioxidant response, could coactivate CAR was investigated in neonatal

Indexed as

AnimalsAnimals, NewbornBilirubinBiomarkersCadmiumConstitutive Androstane ReceptorFemaleGlucuronosyltransferaseHumansIntestinal MucosaIsothiocyanatesMaleMice, KnockoutNF-E2-Related Factor 2Oxidative StressReactive Oxygen SpeciesBilirubinBiomarkersCadmiumConstitutive Androstane ReceptorGlucuronosyltransferaseIsothiocyanatesisothiocyanic acidNfe2l2 protein, mouseNF-E2-Related Factor 2Reactive Oxygen SpeciesReceptors, Cytoplasmic and NuclearUGT1A1 Enzyme

Identifiers

PMID31704714
PMCPMC6904881
OpenAlexW2983563087

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.