ArticleDevelopmental cognitive neuroscience2019
Corticosterone administration targeting a hypo-reactive HPA axis rescues a socially-avoidant phenotype in scarcity-adversity reared rats.
Article in Developmental cognitive neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 38 citations in OpenAlex.
- Acute and persistent neuroendocrine and behavioral alterations after social fear conditioning in adolescent male mice.Journal of neuroendocrinology · 2026Article
- Hearing and early life adversity: effects of developmental stress on sensory processing.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- The protective role of cannabidiol in stress-induced liver injury: modulating oxidative stress and mitochondrial damage.Frontiers in pharmacology · 2025Article
- Unraveling sex differences in maternal and paternal care impacts on social behaviors and neurobiological responses to early-life adversity.Frontiers in neuroendocrinology · 2025Review
- Mothering matters: Towards a better understanding of disrupted infant-caregiver relationships in both mother and offspring.Neurobiology of stress · 2025Review
- Understanding the Development of Chronic Loneliness in Youth.Child development perspectives · 2024Article
- Early life adversity reduces affiliative behavior with a stressed cagemate and leads to sex-specific alterations in corticosterone responses in adult mice.Hormones and behavior · 2024Article
- Socioeconomic Disparities in Hypothalamic-Pituitary-Adrenal Axis Regulation and Prefrontal Cortical Structure.Biological psychiatry global open science · 2024Review
- Exogenous glucocorticoids to improve extinction learning for post-traumatic stress disorder patients with hypothalamic-pituitary-adrenal-axis dysregulation: a study protocol description.European journal of psychotraumatology · 2024Article
- Sex differences in addiction-relevant behavioral outcomes in rodents following early life stress.Addiction neuroscience · 2023Article
- Early Life Stress in Mice Leads to Impaired Colonic Corticosterone Production and Prolonged Inflammation Following Induction of Colitis.Inflammatory bowel diseases · 2023Article
- Amygdala circuit transitions supporting developmentally-appropriate social behavior.Neurobiology of learning and memory · 2023Review
- Molecular Hydrogen: an Emerging Therapeutic Medical Gas for Brain Disorders.Molecular neurobiology · 2023Review
- Infant pain vs. pain with parental suppression: Immediate and enduring impact on brain, pain and affect.PloS one · 2023Article
- Effect of Acute Cold Stress on Neuroethology in Mice and Establishment of Its Model.Animals : an open access journal from MDPI · 2022Article
- Within-person changes in basal cortisol and caregiving modulate executive attention across infancy.Development and psychopathology · 2022Article
- Social support correlates with glucocorticoid concentrations in wild African elephant orphans.Communications biology · 2022Article
- Effects of stress on endophenotypes of suicide across species: A role for ketamine in risk mitigation.Neurobiology of stress · 2022Review
- Adult stress exposure blunts dopamine system hyperresponsivity in a neurodevelopmental rodent model of schizophrenia.Schizophrenia (Heidelberg, Germany) · 2022Article
- Postpartum scarcity-adversity disrupts maternal behavior and induces a hypodopaminergic state in the rat dam and adult female offspring.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
It is well-established that children from low-income, under-resourced families are at increased risk of altered social development. However, the biological mechanisms by which poverty-related adversities can "get under the skin" to influence social behavior are poorly understood and cannot be easily ascertained using human research alone. This study utilized a rodent model of "scarcity-adversity," which encompasses material resource deprivation (scarcity) and reduced caregiving quality (adversity), to explore how early-life scarcity-adversity causally influences social behavior via disruption of developing stress physiology. Results showed that early-life scarcity-adversity exposure increased social avoidance when offspring were tested in a social approach test in peri-adolescence. Furthermore, early-life scarcity-adversity led to blunted hypothalamic-pituitary-adrenal (HPA) axis activity as measured via adrenocorticotropic hormone (ACTH) and corticosterone (CORT) reactivity following the social approach test. Western blot analysis of brain tissue revealed that glucocorticoid receptor levels in the dorsal (but not ventral) hippocampus and medial prefrontal cortex were significantly elevated in scarcity-adversity reared rats following the social approach test. Finally, pharmacological repletion of CORT in scarcity-adversity reared peri-adolescents rescued social behavior. Our findings provide causal support that early-life scarcity-adversity exposure negatively impacts social development via a hypocorticosteronism-dependent mechanism, which can be targeted via CORT administration to rescue social behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.