Evidence map›Paper›PMID 31704565›Full record

ArticleEnvironment international2020

Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment.

Elina Drakvik, Rolf Altenburger, Yasunobu Aoki, Thomas Backhaus, Tina Bahadori, Robert Barouki, Werner Brack, Mark T D Cronin, Barbara Demeneix, Susanne Hougaard Bennekou and 16 more

Abstract readLetter
In one paragraph

Article in Environment international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed.

  1. Association between metal co-exposure and frailty: exploring the potential explanatory pathway of inflammation.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
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  13. An Urban Stormwater Contaminant Signature: Defining Priority Contaminants for Urban Stormwater Research.Water environment research : a research publication of the Water Environment Federation · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Elina DrakvikKarolinska Institutet, Institute of Environmental Medicine, Nobels väg 13, SE-171 77 Stockholm, Sweden; Stockholm University, ACES, SE-106 91 Stockholm, Sweden. Electronic address: elina.drakvik@ki.se.
Rolf AltenburgerHelmholtz Centre for Environmental Research UFZ, Permoserstr. 15, 04318 Leipzig, Germany.
Yasunobu AokiNational Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki 305-8506, Japan.
Thomas BackhausUniversity of Gothenburg, Department of Biological and Environmental Sciences, Box 461, SE-405 30 Gothenburg, Sweden.
Tina BahadoriUS Environmental Protection Agency, 1200 Pennsylvania Ave, NW, MC 8201R, Washington, DC 20460, USA.
Robert BaroukiUniversité de Paris, Inserm Unit 1124, 45 rue des Saints Pères, 75006 Paris, France.
Werner BrackHelmholtz Centre for Environmental Research UFZ, Permoserstr. 15, 04318 Leipzig, Germany; RWTH Aachen University Institute for Environmental Research, ABBt-aachen Biology, Worringerweg 1, 52074 Aachen, Germany.
Mark T D CroninLiverpool John Moores University, School of Pharmacy and Biomolecular Sciences, Byrom Street, Liverpool L3 3AF, UK.
Barbara DemeneixMuséum National d'Histoire Naturelle (MNHN) UMR 7221 (CNRS/MNHN), 7 rue Cuvier, 75005 Paris, France.
Susanne Hougaard BennekouDanish Technical University, FOOD, Kemitorvet 201, 2800 Kgs. Lyngby, Denmark.
Jacob van KlaverenNational Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, the Netherlands.
Carsten KneuerGerman Federal Institute for Risk Assessment, Pesticide Safety, German Federal Institute for Risk Assessment, Max-Dohrn-Str. 8-10, 10589 Berlin, Germany.
Marike Kolossa-GehringGerman Environment Agency (UBA), Corrensplatz 1, 14195 Berlin, Germany.
Erik LebretNational Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, the Netherlands; Institute of Risk Assessment Sciences - IRAS, Utrecht University, Yalelaan 2, 3584 CM Utrecht, the Netherlands.
Leo PosthumaNational Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, the Netherlands; Radboud University, Department of Environmental Science, Institute for Water and Wetland Research, Nijmegen, the Netherlands.
Lena ReiberGerman Environment Agency (UBA), Corrensplatz 1, 14195 Berlin, Germany.
Cynthia RiderNational Toxicology Program, National Institute of Environmental Health Sciences, 111 TW Alexander Drive, PO Box 12233, MD:K2-12, Research Triangle Park, NC 27709, USA.
Joëlle RüeggKarolinska Institutet, Institute of Environmental Medicine, Nobels väg 13, SE-171 77 Stockholm, Sweden; Uppsala University, Department of Organismal Biology, Norbyvägen 18A, SE-752 36 Uppsala, Sweden.
Giuseppe TestaUniversity of Milan, Department of Oncology, Via S. Sofia, 9/1, 20122 Milan, Italy; IEO European Institute of Oncology, Via Adamello 16, 20139 Milan, Italy.
Bart van der BurgBioDetection Systems, Science Park 406, 1098XH Amsterdam, the Netherlands.
Hilko van der VoetWageningen University & Research, Droevendaalsesteeg 1, 6708PB Wageningen, the Netherlands.
A Michael WarhurstCHEM Trust, 34b York Way, London N1 9AB, UK.
Bob van de WaterLeiden Academic Centre for Drug Research, Leiden University, P.O. Box 9502, 2300 RA Leiden, the Netherlands.
Kunihiko YamazakiMinistry of the Environment, Japan, 1-2-2 Kasumigaseki, Chiyoda-ku, Tokyo 100-8975, Japan.
Mattias ÖbergKarolinska Institutet, Institute of Environmental Medicine, Nobels väg 13, SE-171 77 Stockholm, Sweden.
Åke BergmanStockholm University, ACES, SE-106 91 Stockholm, Sweden; Örebro University, Department of Science and Technology, SE-701 82 Örebro, Sweden; State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China.

Funding

Toxicological Assessments for the National Toxicology ProgramZIAES103316 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WALKER, NIGEL J · 2016 to 2019
$31.9M
Toxicological Assessments for the Division of the National Toxicology ProgramZICES103316 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WALKER, NIGEL J · 2020 to 2021
$18.5M
Intramural NIH HHS ZIA ES103316
6 · The paper itself

Abstract

The number of anthropogenic chemicals, manufactured, by-products, metabolites and abiotically formed transformation products, counts to hundreds of thousands, at present. Thus, humans and wildlife are exposed to complex mixtures, never one chemical at a time and rarely with only one dominating effect. Hence there is an urgent need to develop strategies on how exposure to multiple hazardous chemicals and the combination of their effects can be assessed. A workshop, "Advancing the Assessment of Chemical Mixtures and their Risks for Human Health and the Environment" was organized in May 2018 together with Joint Research Center in Ispra, EU-funded research projects and Commission Services and relevant EU agencies. This forum for researchers and policy-makers was created to discuss and identify gaps in risk assessment and governance of chemical mixtures as well as to discuss state of the art science and future research needs. Based on the presentations and discussions at this workshop we want to bring forward the following Key Messages.

Indexed as

Risk AssessmentComplex MixturesHazardous SubstancesHumansComplex MixturesHazardous SubstancesChemical mixturesCombined exposureEnvironmental chemicalsMixture risk assessmentRisk management

Identifiers

PMID31704565
PMCPMC6979318

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.