Evidence map›Paper›PMID 31704553›Full record

ArticleAtherosclerosis2019

Helicobacter pylori infection selectively increases the risk for carotid atherosclerosis in young males.

Linfang Zhang, Zhiheng Chen, Xiujuan Xia, Jingshu Chi, Huan Li, Xiaoming Liu, Rong Li, Yixi Li, Da Liu, Delin Tian and 6 more

Open access · greenAbstract readComparative Study
In one paragraph

Article in Atherosclerosis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Review
  3. Metabolism open · 2025
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  7. Association between triglyceride-glucose index andFrontiers in endocrinology · 2025
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  11. Role ofBiomedicines · 2024
    Review
  12. Article
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  15. Heliyon · 2023
    Article
  16. Article
  17. Infection withFrontiers in pharmacology · 2023
    Review
  18. Pathogens (Basel, Switzerland) · 2022
    Article
  19. Frontiers in microbiology · 2022
    Review
  20. CagAFrontiers in cardiovascular medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Linfang ZhangDepartment of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, China; Center for Precision Medicine and Division of Cardiovascular Medicine, Department of Medicine, University of Missouri School of Medicine, Columbia, MO, USA.
Zhiheng ChenDepartment of Health Management, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China.
Xiujuan XiaDepartment of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, China; Center for Precision Medicine and Division of Cardiovascular Medicine, Department of Medicine, University of Missouri School of Medicine, Columbia, MO, USA.
Jingshu ChiDepartment of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, China.
Huan LiDepartment of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, China.
Xiaoming LiuDepartment of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, China.
Rong LiDepartment of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, China.
Yixi LiCenter for Precision Medicine and Division of Cardiovascular Medicine, Department of Medicine, University of Missouri School of Medicine, Columbia, MO, USA.
Da LiuCenter for Precision Medicine and Division of Cardiovascular Medicine, Department of Medicine, University of Missouri School of Medicine, Columbia, MO, USA.
Delin TianDepartment of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, China.
Hui WangDepartment of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, China.
Greg F PetroskiBiostatistics and Research Design Unit, University of Missouri School of Medicine, Columbia, MO, USA.
Greg C FlakerCenter for Precision Medicine and Division of Cardiovascular Medicine, Department of Medicine, University of Missouri School of Medicine, Columbia, MO, USA.
Hong HaoCenter for Precision Medicine and Division of Cardiovascular Medicine, Department of Medicine, University of Missouri School of Medicine, Columbia, MO, USA.
Zhenguo LiuCenter for Precision Medicine and Division of Cardiovascular Medicine, Department of Medicine, University of Missouri School of Medicine, Columbia, MO, USA. Electronic address: liuzheng@health.missouri.edu.
Canxia XuDepartment of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, China. Electronic address: xucanxia2000@163.com.
Third Xiangya Hospital · CNUniversity of Missouri · USCentral South University · CN

Funding

Helicobacter pylori infection and endothelial dysfunctionR01HL148196 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI LIU, ZHENGUO · 2019 to 2022
$2.6M
Ambient fine particulate matter and bone marrow stem cellsR01ES026200 · NIEHS · UNIVERSITY OF MISSOURI-COLUMBIA · PI LIU, ZHENGUO · 2016 to 2020
$1.7M
NHLBI NIH HHS R01 HL148196NIEHS NIH HHS R01 ES026200
6 · The paper itself

Abstract

BACKGROUND AND

aimsAtherosclerosis is an important contributing factor to cardiovascular mortality. The role of Helicobacter pylori (H. pylori) infection in atherosclerosis is inconsistent and sometimes controversial. The present study aimed to determine if H. pylori infection is associated with carotid atherosclerosis.

methods17,613 males and females with both carotid ultrasonic examination and

resultsAfter adjusting for age, sex, body mass index, lipid profile, hypertension, renal function, diabetes mellitus, and smoking, H. pylori infection was found as an independent risk factor for carotid atherosclerosis in males under 50 years, but not in older males or females (odds ratio 1.229, 95% CI 1.054-1.434, p = 0.009). Follow-up data analysis showed that the incidence of carotid atherosclerosis from no atherosclerosis to detectable lesions was significantly higher in young males with persistent H. pylori infection than those without H. pylori infection (p = 0.028) after 3 years.

conclusionsThese data suggest that H. pylori infection might be an important risk factor for carotid atherosclerosis in young Chinese males under 50.

Indexed as

AdultAgedAge of OnsetCarotid Artery DiseasesChinaCross-Sectional StudiesFemaleHelicobacter InfectionsHelicobacter pyloriHumansIncidenceMaleMiddle AgedPrognosisRetrospective StudiesRisk AssessmentCardiovascular risk factorCarotid atherosclerosisGender differenceHelicobacter pylori

Identifiers

PMID31704553
PMCPMC7349937
OpenAlexW2980052246

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.