Evidence map›Paper›PMID 31704372›Full record

ArticleFree radical biology & medicine2020

Repeated measures of urinary oxidative stress biomarkers and preterm birth in Puerto Rico.

Stephanie M Eick, Kelly K Ferguson, Ginger L Milne, Rafael Rios-McConnell, Carmen Vélez-Vega, Zaira Rosario, Akram Alshawabkeh, José F Cordero, John D Meeker

Open access · greenAbstract read
In one paragraph

Article in Free radical biology & medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 4 pooled it
6.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 4 syntheses or guidelines pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Oxidative stress biomarkers in pregnancy: a systematic review.Reproductive biology and endocrinology : RB&E · 2024
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Review
  7. Elevated Amniotic Fluid 8-Iso-Prostaglandin FAntioxidants (Basel, Switzerland) · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Stephanie M EickProgram on Reproductive Health and the Environment, Department of Obstetrics, Gynecology and Reproductive Services, University of California San Francisco, San Francisco, CA, United States.
Kelly K FergusonEpidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States; Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, United States.
Ginger L MilneDivision of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN, United States.
Rafael Rios-McConnellUniversity of Puerto Rico Graduate School of Public Health, UPR Medical Sciences Campus, San Juan, PR, United States.
Carmen Vélez-VegaUniversity of Puerto Rico Graduate School of Public Health, UPR Medical Sciences Campus, San Juan, PR, United States.
Zaira RosarioUniversity of Puerto Rico Graduate School of Public Health, UPR Medical Sciences Campus, San Juan, PR, United States.
Akram AlshawabkehCollege of Engineering, Northeastern University, Boston, MA, United States.
José F CorderoDepartment of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, GA, United States.
John D MeekerDepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, United States. Electronic address: meekerj@umich.edu.
University of Puerto Rico, Medical Sciences Campus · PRUniversity of Michigan–Ann Arbor · USNortheastern University · USUniversity of California, San Francisco · USUniversity of Georgia · USVanderbilt University Medical Center · US

Funding

Research Experiences and Training Coordination CoreP42ES017198 · NIEHS · NORTHEASTERN UNIVERSITY · PI ALSHAWABKEH, AKRAM N · 2010 to 2024
$38.6M
Environmental Influences on Child Health Outcomes in Puerto Rico (ECHO-PRO)UH3OD023251 · OD · NORTHEASTERN UNIVERSITY · PI Akram N Alshawabkeh · 2018 to 2026
$24.0M
Strategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3M
Environmental Influences on Child Health Outcomes in Puerto Rico (ECHO-PRO)UG3OD023251 · OD · NORTHEASTERN UNIVERSITY · PI ALSHAWABKEH, AKRAM N · 2016 to 2024
$13.0M
Toxicogenomics-based Mechanistic Multimedia Exposure Assessment and Child DevelopmentP50ES026049 · NIEHS · NORTHEASTERN UNIVERSITY · PI GU, APRIL Z · 2015 to 2018
$3.6M
NIEHS NIH HHS P30 ES017885NIEHS NIH HHS P42 ES017198NIEHS NIH HHS P50 ES026049NIH HHS UG3 OD023251NIH HHS UH3 OD023251
6 · The paper itself

Abstract

backgroundPreterm birth (PTB; gestational age <37 weeks), the leading cause of infant morbidity and mortality worldwide, is of particular concern in Puerto Rico. Rates of PTB in Puerto Rico peaked at 20% in 2006, which are historically some of the highest in the world. Oxidative stress and inflammation have been implicated as contributors to adverse birth outcomes, including PTB, and these associations have not been explored in Puerto Rico. Our objective was to examine associations between urinary oxidative stress biomarkers and PTB in the Puerto Rico Testsite for Exploring Contamination Threats (PROTECT) pregnancy cohort (N = 469).

methods8-iso-prostaglandin F

resultsAveraged levels of 8-iso-PGF

conclusionsOur results suggest that oxidative stress and inflammation, as measured by these biomarkers, may be important contributors to PTB. Further research is needed to improve our understanding of the role these biomarkers may play in the causal pathway between environmental factors and PTB.

Indexed as

Premature BirthBiomarkersDinoprostFemaleGestational AgeHumansInfantInfant, NewbornOxidative StressPregnancyPuerto RicoBiomarkersDinoprostEpidemiologyIsoprostanesOxidative stressPreterm birthPuerto RicoRepeated measures

Identifiers

PMID31704372
PMCPMC6942200
OpenAlexW2986073129

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.