Evidence map›Paper›PMID 31703746›Full record

ArticleActa neuropathologica communications2019

Synergistic toxicity in an in vivo model of neurodegeneration through the co-expression of human TDP-43

Alexander J Moszczynski, Madeline Harvey, Niveen Fulcher, Cleusa de Oliveira, Patrick McCunn, Neil Donison, Robert Bartha, Susanne Schmid, Michael J Strong, Kathryn Volkening

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. TDP-43 Proteinopathy and Tauopathy: Do They Have Pathomechanistic Links?International journal of molecular sciences · 2022
    Review
  5. Old age amyotrophic lateral sclerosis and limbic TDP-43 pathology.Brain pathology (Zurich, Switzerland) · 2022
    Article
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Alexander J MoszczynskiMolecular Medicine Research Group, Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, Rm 3246, 100 Perth Dr, London, ON, N6A 5K8, Canada.
Madeline HarveyMolecular Medicine Research Group, Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, Rm 3246, 100 Perth Dr, London, ON, N6A 5K8, Canada.
Niveen FulcherNeuroscience Program, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada.
Cleusa de OliveiraAnatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada.
Patrick McCunnMedical Biophysics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada.
Neil DonisonMolecular Medicine Research Group, Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, Rm 3246, 100 Perth Dr, London, ON, N6A 5K8, Canada.
Robert BarthaMedical Biophysics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada.
Susanne SchmidNeuroscience Program, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Canada.
Michael J StrongMolecular Medicine Research Group, Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, Rm 3246, 100 Perth Dr, London, ON, N6A 5K8, Canada. mstrong@uwo.ca.ORCID 0000-0003-1988-6262
Kathryn VolkeningMolecular Medicine Research Group, Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, Rm 3246, 100 Perth Dr, London, ON, N6A 5K8, Canada.
Western University · CA

Funding

CSRD VA 1
6 · The paper itself

Abstract

Although it has been suggested that the co-expression of multiple pathological proteins associated with neurodegeneration may act synergistically to induce more widespread neuropathology, experimental evidence of this is sparse. We have previously shown that the expression of Thr

Indexed as

AnimalsBehavior, AnimalDisease Models, AnimalDNA-Binding ProteinsFemaleGene Transfer TechniquesHippocampusHumansMotor ActivityNeurodegenerative DiseasesRats, Sprague-DawleyRats, TransgenicSpinal Cordtau ProteinsDNA-Binding ProteinsMAPT protein, humanTARDBP protein, humantau ProteinsAmyotrophic lateral sclerosis with cognitive impairmentComorbid pathologiesMicrotubule associated protein tauNeurodegenerationNeuronal cytoplasmic inclusionsTDP-43

Identifiers

PMID31703746
PMCPMC6839082
OpenAlexW2987519453

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.