Evidence map›Paper›PMID 31703729›Full record

ReviewParasites & vectors2019

The role of the liver in the migration of parasites of global significance.

Gwendoline Deslyper, Derek G Doherty, James C Carolan, Celia V Holland

Abstract readReview
In one paragraph

Review in Parasites & vectors, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Chronic Cholestatic Liver Disease Induced by Larval Ascariasis: Novel Insights Into Immune-Mediated Pathogenesis and Hepatic Fibrosis in Mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Liver Proteome Alterations in Red Deer (Pathogens (Basel, Switzerland) · 2022
    Article
  11. Review
  12. Article
  13. The long and winding road ofParasitology · 2021
    Article
  14. Immune responses in liver and spleen againstJournal of advanced research · 2020
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gwendoline DeslyperDepartment of Zoology, School of Natural Sciences, Trinity College Dublin, Dublin 2, Ireland. deslypeg@tcd.ie.
Derek G DohertySchool of Medicine, Trinity College Dublin, Dublin 2, Ireland.
James C CarolanDepartment of Biology, Maynooth University, Maynooth, Co. Kildare, Ireland.
Celia V HollandDepartment of Zoology, School of Natural Sciences, Trinity College Dublin, Dublin 2, Ireland.

Funding

Frank Jeal Scholarship Frank Jeal ScholarshipIrish Research Council GOIPG/2016/551
6 · The paper itself

Abstract

Many parasites migrate through different tissues during their life-cycle, possibly with the aim to enhance their fitness. This is true for species of three parasite genera of global importance, Ascaris, Schistosoma and Plasmodium, which cause significant global morbidity and mortality. Interestingly, these parasites all incorporate the liver in their life-cycle. The liver has a special immune status being able to preferentially induce tolerance over immunity. This function may be exploited by parasites to evade host immunity, with Plasmodium spp. in particular using this organ for its multiplication. However, hepatic larval attrition occurs in both ascariasis and schistosomiasis. A better understanding of the molecular mechanisms involved in hepatic infection could be useful in developing novel vaccines and therapies for these parasites.

Indexed as

Life Cycle StagesAnimalsAscarisHumansLiverPlasmodiumSchistosomaAscarisImmunotoleranceLiverMigrationPlasmodiumSchistosoma

Identifiers

PMID31703729
PMCPMC6842148

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.