ArticleBMC oral health2019
Predictive factors related to the progression of periodontal disease in patients with early rheumatoid arthritis: a cohort study.
Article in BMC oral health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- The Association between Dry Mouth and the Periodontal Status in Older Adults Undergoing Supportive Periodontal Therapy.European journal of dentistry · 2026Article
- Gene variants for the WNT pathway are associated with severity in periodontal disease.Clinical oral investigations · 2024Article
- The Interaction Effect of Anti-RgpA and Anti-PPAD Antibody Titers: An Indicator for Rheumatoid Arthritis Diagnosis.Journal of clinical medicine · 2023Article
- Adipokines and periodontal markers as risk indicators of early rheumatoid arthritis: a cross-sectional study.Clinical oral investigations · 2021Article
- Risk Factors for Developing Rheumatoid Arthritis in Patients With Undifferentiated Arthritis and Inflammatory Arthralgia.Frontiers in medicine · 2021Review
- Periodontal Disease in Diabetes Mellitus: A Case-Control Study in Smokers and Non-Smokers.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2020Article
- Effects of nonsurgical periodontal therapy in patients with rheumatoid arthritis: a prospective before and after study.Colombia medica (Cali, Colombia)Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRheumatoid arthritis (RA) and periodontal disease are inter-related conditions. However, factors predictive of periodontal disease progression in patients with early rheumatoid arthritis (eRA) are lacking. The aim of this study was to identify factors associated with the progression of clinical attachment loss (CAL) in interproximal dental sites of eRA patients.
methodsTwenty-eight eRA patients were evaluated for the progression of CAL at 280 interproximal dental sites at 1 year of follow-up. Markers of RA activity (rheumatoid factor, erythrocyte sedimentation rate, and C-reactive protein), a marker of bone resorption (Dickkopf-related protein 1), Disease Activity Score 28 and Simple Disease Activity Index were included as potential systemic predictive factors. Plaque index, gingival index, pocket depth, clinical attachment level and Dickkopf-related protein 1 in crevicular fluid at baseline were included as potential local predictive factors. Data were analysed in a hierarchical structure using generalised linear mixed models for progression at each site (> 2 mm) during follow-up.
resultsC-reactive protein level was the most important predictive systemic factor for the progression of CAL. The mean CAL and a high degree of gingival inflammation in interproximal sites at baseline were important predictive local factors (p < 0.0001). Patients who received combined treatment with disease-modifying antirheumatic drugs and corticosteroids exhibited less CAL (p < 0.0001). The predictive value of the generalised linear mixed model for progression was 85%.
conclusionsSystemic factors, including RA disease activity and baseline periodontal condition, were associated with periodontal progression. Pharmacological treatment may affect periodontal progression in patients with early RA.
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