Evidence map›Paper›PMID 31703609›Full record

ArticleJournal for immunotherapy of cancer2019

Guillain-Barre syndrome observed with adoptive transfer of lymphocytes genetically engineered with an NY-ESO-1 reactive T-cell receptor.

Jocelyn Joseph, Michael J Nathenson, Van Anh Trinh, Karan Malik, Erica Nowell, Kristen Carter, Shiao-Pei Weathers, George D Demetri, Dejka Araujo, Anthony P Conley

Open access · goldAbstract readCase Reports
In one paragraph

Article in Journal for immunotherapy of cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. NY-ESO-1 antigen: A promising frontier in cancer immunotherapy.Clinical and translational medicine · 2024
    Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Targeting cancer testis antigens in synovial sarcoma.Journal for immunotherapy of cancer · 2021
    Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jocelyn JosephDepartment of Clinical Pharmacy Services, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, USA. jtjoseph@mdanderson.org.ORCID 0000-0002-5618-0819
Michael J NathensonCenter for Sarcoma and Bone Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave, Brighton, MA, USA.
Van Anh TrinhDepartment of Clinical Pharmacy Services, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, USA.
Karan MalikCenter for Sarcoma and Bone Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave, Brighton, MA, USA.
Erica NowellDepartment of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, USA.
Kristen CarterDepartment of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, USA.
Shiao-Pei WeathersDepartment of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, USA.
George D DemetriCenter for Sarcoma and Bone Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave, Brighton, MA, USA.
Dejka AraujoDepartment of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, USA.
Anthony P ConleyDepartment of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, USA.
The University of Texas MD Anderson Cancer Center · USDana-Farber Cancer Institute · US

Funding

Convalescent Plasma to Limit Coronavirus Associated ComplicationsUL1TR003167 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KARP, DANIEL D, MCPHERSON, DAVID D · 2019 to 2023
$45.3M
NCATS NIH HHS UL1 TR003167
6 · The paper itself

Abstract

backgroundAdoptive transfer of autologous T-lymphocytes transduced with a high affinity NY-ESO-1-reactive T-cell receptor (NY-ESO-1 CASE PRESENTATION: A 47 year-old woman and 39 year-old woman with refractory metastatic SS were treated with fludarabine-cyclophosphamide lymphodepletion followed by adoptive transfer of NY-ESO-1

conclusionsGiven the expanding applications of immunotherapy in cancer management, clinicians should stay vigilant against the potential development of unusual but life-threatening immune-mediated toxicities.

Indexed as

Adoptive TransferAdultAntigens, NeoplasmFemaleGenetic EngineeringGuillain-Barre SyndromeHumansMembrane ProteinsMiddle AgedReceptors, Antigen, T-CellSarcoma, SynovialT-LymphocytesAntigens, NeoplasmCTAG1B protein, humanMembrane ProteinsReceptors, Antigen, T-CellAdoptive T-cell transferGuillain-Barre syndromeNY-ESO-1Synovial sarcoma

Identifiers

PMID31703609
PMCPMC6842215
OpenAlexW2987025955

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.